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 Indian J Med Microbiol  
 

Figure 7: Histopathological changes in the oral mucosa of rats at different observation periods during treatment of OSMF: 7a - 4 months induction: very thin epithelial lining (a), thick collagen deposition in submucosa (b), white patch in the mucosa (c); 7b - 1 month treatment: atrophic epithelium (a), dense collagen deposition in submucosa (b), pale pink coloured mucosa (c); 7c - 2 months treatment: epithelium regaining its normal thickness (a), moderate decrease in collagen in submucosa (b), appearance of blood capillaries in mucosal layer (c); 7d – 4 months treatment: epithelium almost regaining its normal thickness (a), more than 80 % dissolution of collagen in submucosa (b)

Figure 7: Histopathological changes in the oral mucosa of rats at different observation periods during treatment of OSMF: 7a - 4 months induction: very thin epithelial lining (a), thick collagen deposition in submucosa (b), white patch in the mucosa (c); 7b - 1 month treatment: atrophic epithelium (a), dense collagen deposition in submucosa (b), pale pink coloured mucosa (c); 7c - 2 months treatment: epithelium regaining its normal thickness (a), moderate decrease in collagen in submucosa (b), appearance of blood capillaries in mucosal layer (c); 7d – 4 months treatment: epithelium almost regaining its normal thickness (a), more than 80 % dissolution of collagen in submucosa (b)