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 Indian J Med Microbiol  
 

Figure 4: Cyclin D1 gene expression integrates mitogenic signals as well as their oncogenic alterations, which are frequently observed in hepatocellular carcinoma. MicroRNA miR-195 and -520 targeting cyclin D1 transcripts are downregulated in hepatocellular carcinoma. These alterations induce overexpression of the cyclin D1 protein in the nucleus due to the absence of T286 phosphorylation, impairing its nuclear export as a result of increased level of Akt in hepatocellular carcinoma (Adapted from Bisteau X, Caldez MJ, Kaldis P. The complex relationship between liver cancer and the cell cycle: A story of multiple regulations. Cancers 2014;6:79-111)

Figure 4: Cyclin D1 gene expression integrates mitogenic signals as well as their oncogenic alterations, which are frequently observed in hepatocellular carcinoma. MicroRNA miR-195 and -520 targeting cyclin D1 transcripts are downregulated in hepatocellular carcinoma. These alterations induce overexpression of the cyclin D1 protein in the nucleus due to the absence of T286 phosphorylation, impairing its nuclear export as a result of increased level of Akt in hepatocellular carcinoma (Adapted from Bisteau X, Caldez MJ, Kaldis P. The complex relationship between liver cancer and the cell cycle: A story of multiple regulations. Cancers 2014;6:79-111)