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 Indian J Med Microbiol  
 

Figure 3: Crosstalk between retinoblastoma and p53 pathway. This pathway suggests that cyclin D1 regulated p53 through p21 which indicates a potential crosstalk. The blue circles indicate the oncogenes (cyclin D1 and mdm2) while green squares indicate tumor suppressor genes (p53, p16, and retinoblastoma) (Adapted from: Roy PG, Thompson AM. Cyclin D1 and breast cancer. Breast 2006;15:718-27)

Figure 3: Crosstalk between retinoblastoma and p53 pathway. This pathway suggests that cyclin D1 regulated p53 through p21 which indicates a potential crosstalk. The blue circles indicate the oncogenes (cyclin D1 and mdm2) while green squares indicate tumor suppressor genes (p53, p16, and retinoblastoma) (Adapted from: Roy PG, Thompson AM. Cyclin D1 and breast cancer. Breast 2006;15:718-27)