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 Indian J Med Microbiol  
 

Figure 2: Regulation of G1-S transition. Mitogenic signals promote the assembly of cyclin D1 and cyclin-dependent kinase 4/6 which in turn sequester the other Cip proteins. Thereby, they activate the cyclin E and cyclin-dependent kinase 2 complexes. These cyclin D and E-dependent kinases phosphorylate retinoblastoma gene resulting in liberation of E2F transcription factor, which in turn activates various genes responsible for progression of S-phase

Figure 2: Regulation of G1-S transition. Mitogenic signals promote the assembly of cyclin D1 and cyclin-dependent kinase 4/6 which in turn sequester the other Cip proteins. Thereby, they activate the cyclin E and cyclin-dependent kinase 2 complexes. These cyclin D and E-dependent kinases phosphorylate retinoblastoma gene resulting in liberation of E2F transcription factor, which in turn activates various genes responsible for progression of S-phase