Indian Journal of Dental Research

ORIGINAL RESEARCH
Year
: 2020  |  Volume : 31  |  Issue : 2  |  Page : 277--281

PECAM-1 overexpression signifies aggressive biologic behavior of oral lichen planus – A pilot study


A Lavanya, Wafa Khan, Preeti Singh, Dominic Augustine, Roopa S Rao, SV Sowmya, Vanishri C Haragannavar, K Shwetha Nambiar 
 Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, M S Ramaiah University of Applied Sciences, M S R Nagar, Bangalore, Karnataka, India

Correspondence Address:
Dr. A Lavanya
Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, M S Ramaiah University of Applied Sciences, M S R Nagar, Bangalore . 560 054, Karnataka
India

Context: The etiopathogenesis of oral lichen planus (OLP) is still debatable. According to literature, many studies have illustrated OLP as a T-cell-mediated chronic autoimmune disease. Currently, there is increased evidence of chronic inflammation in OLP and its association with vascular adhesion molecules (VAMs). Aim: The aim of this study was to evaluate the expression of VAM (PECAM-1) in OLP. Setting and Design: Tissue samples involved 20 archival cases of histopathologically confirmed OLP (n = 15) and normal mucosa (n = 5) as controls. Materials and Methods: The sections were subjected to immunohistochemical analysis using antibody to PECAM-1. Brown staining of the endothelial cells of blood vessels was considered positive. The expression of PECAM-1 in OLP was statistically analyzed using Wilcoxon sign-rank test. Results: The expression of PECAM-1 in OLP was statistically significant when compared with normal mucosa (P < 0.05). A statistically significant difference was also observed in PECAM-1 expression between the reticular type and erosive type of OLP. Conclusion: PECAM-1 was found to be overexpressed in OLP; difference in PECAM-1 expression was noted between the reticular and erosive types. The VAMs could be exploited as a possible therapeutic target in OLP to modulate the disease process thereby reducing the dependency on corticosteroids.


How to cite this article:
Lavanya A, Khan W, Singh P, Augustine D, Rao RS, Sowmya S V, Haragannavar VC, Nambiar K S. PECAM-1 overexpression signifies aggressive biologic behavior of oral lichen planus – A pilot study.Indian J Dent Res 2020;31:277-281


How to cite this URL:
Lavanya A, Khan W, Singh P, Augustine D, Rao RS, Sowmya S V, Haragannavar VC, Nambiar K S. PECAM-1 overexpression signifies aggressive biologic behavior of oral lichen planus – A pilot study. Indian J Dent Res [serial online] 2020 [cited 2021 Jun 25 ];31:277-281
Available from: https://www.ijdr.in/article.asp?issn=0970-9290;year=2020;volume=31;issue=2;spage=277;epage=281;aulast=Lavanya;type=0