Indian Journal of Dental Research

ORIGINAL RESEARCH
Year
: 2018  |  Volume : 29  |  Issue : 3  |  Page : 280--285

Effect of nonsurgical periodontal therapy on interleukin-34 levels in periodontal health and disease


CN Guruprasad, AR Pradeep 
 Department of Periodontology, Government Dental College and Research Institute, Bengaluru, Karnataka, India

Correspondence Address:
Dr. C N Guruprasad
Department of Periodontology, Government Dental College and Research Institute, Bengaluru - 560 002, Karnataka
India

Background: Interleukin-34 (IL-34) is a recently identified alternative ligand for colony-stimulating factor-1 receptor plays an important role in osteoclastogenesis. The aim of this study was to evaluate the IL-34 levels in gingival crevicular fluid (GCF) and plasma in subjects with chronic periodontitis and to evaluate the effect of nonsurgical periodontal therapy on the GCF and plasma IL-34 levels. Materials and Methods: Thirty individuals (age range: 30–56 years) were selected and divided into groups based on the gingival index, probing pocket depth, clinical attachment level, and radiologic parameters (bone loss): Group I (15 individuals with healthy periodontium), Group II (15 individuals with chronic generalized periodontitis) while Group II patients after 8 weeks of the treatment (scaling and root planning) constituted Group III. GCF samples and plasma samples were collected to estimate the levels of IL-34 using enzyme-linked immunosorbent assay kit. Results: The mean IL-34 concentration in GCF and plasma was highest for Group II compared to Group I and decreased after nonsurgical periodontal therapy in chronic generalized periodontitis group. The difference between them was statistically significant (P < 0.05). Conclusion: IL-34 can be considered as an “inflammatory marker” of periodontal disease and can be explored in the future as a potential therapeutic target in the treatment of periodontal disease.


How to cite this article:
Guruprasad C N, Pradeep A R. Effect of nonsurgical periodontal therapy on interleukin-34 levels in periodontal health and disease.Indian J Dent Res 2018;29:280-285


How to cite this URL:
Guruprasad C N, Pradeep A R. Effect of nonsurgical periodontal therapy on interleukin-34 levels in periodontal health and disease. Indian J Dent Res [serial online] 2018 [cited 2021 Sep 22 ];29:280-285
Available from: https://www.ijdr.in/article.asp?issn=0970-9290;year=2018;volume=29;issue=3;spage=280;epage=285;aulast=Guruprasad;type=0