Indian Journal of Dental Research

ORIGINAL RESEARCH
Year
: 2017  |  Volume : 28  |  Issue : 2  |  Page : 122--125

Assessing alpha-tocopherol levels in patients with keratocystic odontogenic tumor: A cross-sectional study


Bhargavi Krishna Ayinampudi, Sushmita Bhargavi Varikoti, Pacha Venkat Baghirath, B Hari Vinay, Gayathri, Ashalata Gannepalli 
 Department of Oral and Maxillofacial Pathology, Panineeya Mahavidyalaya Institute of Dental Sciences, Hyderabad, Telangana, India

Correspondence Address:
Bhargavi Krishna Ayinampudi
Department of Oral and Maxillofacial Pathology, Panineeya Mahavidyalaya Institute of Dental Sciences, Hyderabad, Telangana
India

Aims and Objectives: A keratocystic odontogenic tumour (KCOT) is a benign uni- or multicystic, intraosseous tumour of odontogenic origin, with a characteristic lining of parakeratinized stratified squamous epithelium and potential for aggressive, infiltrative behaviour. Various studies in hamsters showed that, alpha-Tocopherol, which is an active biological form of Vitamin E, is a potent antioxidant known to inhibit tumour formation and also regression of established tumours. So, the aim of the present pilot study was to assess the levels of Alpha-Tocopherol(Vitamin E) in Patients with KCOT and compare them with Vitamin E levels in normal healthy individuals. Materials and Methods: A sample of 20 individuals were taken and Alpha Tocopherol levels in serum were assessed. Independent sample t test was used to analyse the data. Serum Vitamin-E levels were found to be decreased in KCOT cases. Results: Mean Vitamin-E level was found to be decreased (mean + S.D. = 10,549.34 +/- 2494.21 ng/mL) as compared to healthy controls (mean + S.D. = 13,982.42 +/- 2178.02 ng/mL). The reduction in serum vitamin E level was statistically significant (P < 0.05). Conclusion: The reduction in Vitamin E levels in KCOT patients might be suggestive of the possible interrelation between Vitamin E and KCOT invivo. Also, increase in intake of Vitamin E might help in reducing the risk of recurrence in KCOT by reducing the dysregulation of Cyclin D1 and Down-Regulation of mutant p53.


How to cite this article:
Ayinampudi BK, Varikoti SB, Baghirath PV, Vinay B H, Gayathri, Gannepalli A. Assessing alpha-tocopherol levels in patients with keratocystic odontogenic tumor: A cross-sectional study.Indian J Dent Res 2017;28:122-125


How to cite this URL:
Ayinampudi BK, Varikoti SB, Baghirath PV, Vinay B H, Gayathri, Gannepalli A. Assessing alpha-tocopherol levels in patients with keratocystic odontogenic tumor: A cross-sectional study. Indian J Dent Res [serial online] 2017 [cited 2021 Nov 30 ];28:122-125
Available from: https://www.ijdr.in/article.asp?issn=0970-9290;year=2017;volume=28;issue=2;spage=122;epage=125;aulast=Ayinampudi;type=0