Indian Journal of Dental Research

ORIGINAL RESEARCH
Year
: 2012  |  Volume : 23  |  Issue : 5  |  Page : 565--567

Immuno-localization of glucose transporter 4 in healthy human gingiva


Suresh Ranga Rao1, Sandhya Sundaram2, Vamsi Lavu1 
1 Department of Periodontics, Faculty of Dental Sciences, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Chennai, India
2 Department of Pathology, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Chennai, India

Correspondence Address:
Suresh Ranga Rao
Department of Periodontics, Faculty of Dental Sciences, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Chennai
India

Background: The gingiva has been shown to be a target tissue for several hormones. Insulin induces uptake of glucose in the peripheral tissues by upregulating the Glucose transporter 4 expression. Little information is available on the expression of Glucose transporter 4 in human gingiva. Aim: In this regard, a pilot study was performed with the aim of determining the distribution pattern of Glucose transporter 4 in healthy human gingiva. Materials and Methods: Immuno-histochemistry was performed on 10 mounted sections of healthy human gingiva with the primary antibody Glucose Transporter 4 (GLUT 4). Appropriate positive and negative controls were used. Results: Glucose transporter 4 expression was observed in the basal and suprabasal layers of the gingival epithelium and fibroblasts of the gingival connective tissue. Conclusion: This may be the first study to demonstrate the expression of GLUT 4 in the healthy human gingiva. The results of this study raise the possibility that gingiva may serve as a target tissue for insulin action.


How to cite this article:
Rao SR, Sundaram S, Lavu V. Immuno-localization of glucose transporter 4 in healthy human gingiva.Indian J Dent Res 2012;23:565-567


How to cite this URL:
Rao SR, Sundaram S, Lavu V. Immuno-localization of glucose transporter 4 in healthy human gingiva. Indian J Dent Res [serial online] 2012 [cited 2021 Sep 25 ];23:565-567
Available from: https://www.ijdr.in/article.asp?issn=0970-9290;year=2012;volume=23;issue=5;spage=565;epage=567;aulast=Rao;type=0