Indian Journal of Dental Research

REVIEW ARTICLE
Year
: 2010  |  Volume : 21  |  Issue : 2  |  Page : 270--274

Role of genes in oro-dental diseases


B Kavitha, Vijayashree Priyadharshini, B Sivapathasundharam, TR Saraswathi 
 Department of Oral and Maxillofacial Pathology, Meenakshi Ammal Dental College and Hospital, Chennai, India

Correspondence Address:
B Kavitha
Department of Oral and Maxillofacial Pathology, Meenakshi Ammal Dental College and Hospital, Chennai
India

In oral cavity, the spectrum of diseases due to genetic alterations ranges from developmental disturbances of teeth to the pre-cancerous and cancerous lesions. Of late, significant progress has been made in the molecular analysis of tumors. With molecular genetic testing emerging as diagnostic, prognostic, and therapeutic approach, a review of genetic alterations ranging from the development of oro-facial structures to the tumors in the head and neck region are addressed in this article. The functional regulatory aspect of genes in relation to oro-facial structures are discussed separately, i.e., in relation to tooth genesis, tooth agenesis (non-syndromic, syndromic), tooth structural alterations, syndromic oro-facial defects, bone diseases, skin diseases (genodermatoses), and malignant tumors. In this literature, various genes involved in the development of the oro-facial structures and tooth in particular are discussed. The genetic basis of disorders in the tooth development (agenesis, hypodontia), tooth structural defects like amelogenesis imperfecta (AI), dentinogenesis imperfecta (DI), and oro-facial structural alterations (various syndromes) are explained.


How to cite this article:
Kavitha B, Priyadharshini V, Sivapathasundharam B, Saraswathi T R. Role of genes in oro-dental diseases.Indian J Dent Res 2010;21:270-274


How to cite this URL:
Kavitha B, Priyadharshini V, Sivapathasundharam B, Saraswathi T R. Role of genes in oro-dental diseases. Indian J Dent Res [serial online] 2010 [cited 2021 May 13 ];21:270-274
Available from: https://www.ijdr.in/article.asp?issn=0970-9290;year=2010;volume=21;issue=2;spage=270;epage=274;aulast=Kavitha;type=0