Indian Journal of Dental Research

ORIGINAL RESEARCH
Year
: 2010  |  Volume : 21  |  Issue : 2  |  Page : 218--223

Diagnostic efficiency of toluidine blue with Lugol俟Q製 iodine in oral premalignant and malignant lesions


Kamarthi Nagaraju1, Shiva Prasad2, L Ashok2 
1 Department of Oral Medicine and Radiology, Subharti Dental College, NH-58, Subharti Puram, Meerut - 250 002, India
2 Department of Oral Medicine and Radiology, Bapuji Dental College, Davangere, India

Correspondence Address:
Kamarthi Nagaraju
Department of Oral Medicine and Radiology, Subharti Dental College, NH-58, Subharti Puram, Meerut - 250 002
India

Background and Objectives: In vivo stains are prompt resources, which have emerged, in the recent years, to aid as clinical diagnostic tools in detecting early premalignant and malignant lesions. The aim of the study was to determine the diagnostic efficiency of toluidine blue with Lugol俟Q製 iodine in oral premalignancies and malignancies and to evaluate the reliability of in vivo staining with toluidine blue and Lugol俟Q製 iodine in the lesions at risk of malignancy. Materials and Methods: The study group comprised 30 subjects with clinically suspicious premalignant lesions and 30 subjects with clinically suspicious malignant lesions. All the lesions were stained consecutively with toluidine blue and Lugol俟Q製 iodine and the dye retention were recorded with photographs. Depending on the retention of the dyes, the biopsy site was determined. The biopsy specimens were sent for histological confirmation and results were statistically analyzed. Results: The overall diagnostic accuracy of Lugol俟Q製 iodine when used consecutively with toluidine blue stain in distinguishing premalignant lesions and malignant lesions was 90%. As the degree of differentiation of malignant lesions progressed toward more severity, they failed to show the retention of Lugol俟Q製 iodine and the result was highly significant statistically, with a P value < 0.001. Interpretation and Conclusion: Lugol俟Q製 iodine when used with toluidine blue helped in delineating the inflammatory lesions and was the mean source in determining clinically the degrees of differentiation of malignant lesions as the poorly differentiated malignant lesions without glycogen content failed to show Lugol俟Q製 iodine retention. Toluidine blue with Lugol俟Q製 iodine can be used as a pretherapeutic assessment of the biologic aggressiveness of the disease.


How to cite this article:
Nagaraju K, Prasad S, Ashok L. Diagnostic efficiency of toluidine blue with Lugol's iodine in oral premalignant and malignant lesions.Indian J Dent Res 2010;21:218-223


How to cite this URL:
Nagaraju K, Prasad S, Ashok L. Diagnostic efficiency of toluidine blue with Lugol's iodine in oral premalignant and malignant lesions. Indian J Dent Res [serial online] 2010 [cited 2021 May 14 ];21:218-223
Available from: https://www.ijdr.in/article.asp?issn=0970-9290;year=2010;volume=21;issue=2;spage=218;epage=223;aulast=Nagaraju;type=0