Indian Journal of Dental ResearchIndian Journal of Dental ResearchIndian Journal of Dental Research
HOME | ABOUT US | EDITORIAL BOARD | AHEAD OF PRINT | CURRENT ISSUE | ARCHIVES | INSTRUCTIONS | SUBSCRIBE | ADVERTISE | CONTACT
Indian Journal of Dental Research   Login   |  Users online: 789

Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size         

 
ORIGINAL ARTICLE
Ahead of Print

Efficacy of antioxidants therapy on progression of periodontal disease – A randomized control trial


1 Department of Periodontology, Government Dental College, Raipur, Chhattisgarh, India
2 Department of Oral Pathology, Government Dental College, Raipur, Chhattisgarh, India
3 Post Graduate Student, New Horizon Dental College and Research Institute, Bilaspur, Chhattisgarh, India

Correspondence Address:
Ritunja Singh,
Post Graduate Student, New Horizon Dental College and Research Institute, Bilaspur, Chhattisgarh - 495 001
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijdr.IJDR_227_20

Background and Aim: Increased oxidative stress has emerged as one of the prime factors in the pathogenesis of periodontitis. Hence, antioxidant therapy may become a promising tool in the treatment of periodontal disease. Uric acid is a major salivary antioxidant, levels of which decrease in periodontitis. The aim of the present study was to investigate the effect of antioxidant therapy on the progression of periodontal disease. Material and Methods: This is a randomized controlled clinical trial conducted among 48 systemically healthy participants having generalized gingivitis with probing depth <3 mm, plaque index (PI) <1, and no bone and attachment loss. Participants were randomly assigned equally (n = 24) into two groups (test and control) using the lottery method. Full mouth scaling and root planning were performed in both the groups and oral hygiene instructions were given. Periodontal assessment at baseline 1 h after scaling and root planning was done with clinical parameters by a single examiner. Test group was prescribed; the commercially available anti-oxidant containing natural lycopene with green tea extract. Sample collection was done for both the groups at baseline and at the 45th day. Results: It was observed that significantly high results were obtained during intra-group comparison for both modified plaque index and sulcus bleeding index from baseline to 45 days. After treatment, a very highly significant increase (P ≤ 0.001) in the test group and significant (P ≤ 0.05) increase in the control group were observed in salivary uric acid levels. Conclusion: Oral lycopene and green tea extract supplementation is positively associated with salivary uric acid levels and plays an important role in the management of gingivitis.


Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Wasti J
    -  Wasti A
    -  Singh R
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed29    
    PDF Downloaded9    

Recommend this journal