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SHORT COMMUNICATION Table of Contents   
Year : 2020  |  Volume : 31  |  Issue : 6  |  Page : 963-966
Prevention of dental caries by regular overnight application of a low-concentration fluoride gel loaded in a custom tray in patients undergoing radiotherapy for head and neck cancer: A preliminary study


1 Department of Oral Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
2 Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
3 Kyushu Dental University School of Oral Health Sciences, Kitakyushu, Fukuoka, Japan
4 Oral Management Center, Nagasaki University Hospital, Nagasaki, Japan

Correspondence Address:
Dr. Souichi Yanamoto
Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588
Japan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijdr.IJDR_138_20

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Background:</bold> Some studies have reported topical application of 1.0%–2.0% fluoride gel in a custom tray for 4–5 minutes every day for the prevention of radiation-related dental caries. However, in Japan, the concentration of fluoride used by patients is limited to less than 0.15%. The efficacy of a low-concentration fluoride gel in a custom tray for the prevention of radiation-related dental caries has not been investigated. <bold>Methods and Material:</bold> In this preliminary study, we enrolled 13 patients with head and neck cancer who underwent radiotherapy. They wore a custom tray containing 0.145% sodium fluoride gel during sleep every night and were examined for newly developed dental caries 1 year later. <bold>Results:</bold> No new dental caries were found in the 13 patients 1 year after radiotherapy, and no adverse events were observed. <bold>Conclusions:</bold> We conclude that low-concentration fluoride gel in a custom tray during sleep could prevent radiation-related dental caries, and we plan to conduct a multi-center phase III randomized controlled trial to examine the efficacy of this method for the prevention of radiation-related dental caries.


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