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CASE REPORT Table of Contents   
Year : 2020  |  Volume : 31  |  Issue : 5  |  Page : 813-818
Usefulness of advanced-platelet rich fibrin (A-PRF) and injectable-platelet rich fibrin (i-PRF) in the management of a massive medication-related osteonecrosis of the jaw (MRONJ): A 5-years follow-up case report


1 School of Dentistry, Department of Health Sciences; Unit of Oral and Maxillofacial Surgery, “Magna Græcia” University of Catanzaro, Italy
2 School of Dentistry, Department of Health Sciences, “Magna Græcia” University of Catanzaro, Italy

Correspondence Address:
Dr. Alessandro Antonelli
School of Dentistry, Department of Health Sciences, “Magna Graecia” University of Catanzaro, Viale Europa, Località Germaneto – 88100, Catanzaro
Italy
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijdr.IJDR_689_19

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Medication-related osteonecrosis of the jaw (MRONJ) is a recurring complication resulting from the long-term therapy with bisphosphonates or antiresorptive drugs such as denosumab or antiangiogenic drugs. This paper describes a 5-years follow-up case of Stage 3 of MRONJ (AAOMS) in a 69-year-old patient treated with piezosurgery and topical application of platelet-rich fibrin (PRF). Medical treatment included antibiotic therapy and a topical treatment with PRF in solid and liquid form. This treatment showed initially the reduction of pain and leakage exudate and a complete wound healing in 25 days. The Injectable-Platelet Rich Fibrin (i-PRF) injections led to a complete resolution of oro-cutaneous fistulas in 50 days showing its ability of releasing growth factors and chemotaxis agents involved in tissue repair mechanisms. Preparation simplicity and the low cost of PRF allow to consider this method as an excellent alternative treatment for the healing of tissues in MRONJ patients.


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