Indian Journal of Dental ResearchIndian Journal of Dental ResearchIndian Journal of Dental Research
HOME | ABOUT US | EDITORIAL BOARD | AHEAD OF PRINT | CURRENT ISSUE | ARCHIVES | INSTRUCTIONS | SUBSCRIBE | ADVERTISE | CONTACT
Indian Journal of Dental Research   Login   |  Users online: 617

Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size         

 


 
ORIGINAL RESEARCH Table of Contents   
Year : 2020  |  Volume : 31  |  Issue : 4  |  Page : 531-536
Estimation and comparison of serum cotinine level among individuals with smoking and tobacco chewing habit


Department of Oral Pathology, Meenakshi Academy of Higher Education and Research, Faculty of Dentistry, Meenakshi Ammal Dental College, Maduravoyal, Chennai, India

Correspondence Address:
Dr. Manoj Prabhakar
Department of Oral Pathology, Meenakshi Academy of Higher Education and Research, Faculty of Dentistry, Meenakshi Ammal Dental College, Alapakkam Main Road, Maduravoyal - 600 095, Chennai
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijdr.IJDR_558_18

Rights and Permissions

Aims and Objectives: The present study was aimed to estimate and compare tobacco exposure in smokers and chewers. The levels of cotinine, one of the constituents of tobacco were considered as indicative of tobacco exposure. Serum Cotinine levels in individuals with the habit of smoking and tobacco chewing were estimated and compared. Base line values of cotinine levels in normal subjects were established. Materials and Methods: The study groups comprised about 30 individuals with the habit of smoking (Group A); these 30 individuals with the habit of tobacco chewing (Group B), and 20 individuals who were never exposed to any form of tobacco as control group (Group C). Serum cotinine levels were estimated using a commercially available enzyme-linked immunosorbent assay in both test and control groups and the difference in the levels were compared. Results: In individuals with the habit of smoking, cotinine levels ranged between 11 ng/ml and 215 ng/ml with a mean concentration of 87.56. In tobacco chewers, the levels ranged between 11 ng/ml and 128 ng/ml with a mean concentration of 73.66. In control group, the levels ranged between 0.34 ng/ml to 2.5 ng/ml with a mean concentration of 0.93. Cotinine levels between smokers and tobacco chewers were compared and there was no statistically significant difference. Conclusion: Difference in serum cotinine levels between smokers and tobacco chewers is not significant. The fact that cotinine level is influenced by age of the individual, frequency and duration of the habit seems to be irrelevant from the results obtained from this study. Prospective studies considering all the factors and variables, with a preferable larger sample size can probably eradicate the chaos on the reliability of cotinine as a predictive biomarker for the amount of tobacco exposure.


[FULL TEXT] [PDF]*
Print this article     Email this article

 
 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
  Citation Manager
 Access Statistics
  Reader Comments
  Email Alert *
  Add to My List *
 
 

 Article Access Statistics
    Viewed117    
    Printed0    
    Emailed0    
    PDF Downloaded16    
    Comments [Add]    

Recommend this journal