Indian Journal of Dental ResearchIndian Journal of Dental ResearchIndian Journal of Dental Research
HOME | ABOUT US | EDITORIAL BOARD | AHEAD OF PRINT | CURRENT ISSUE | ARCHIVES | INSTRUCTIONS | SUBSCRIBE | ADVERTISE | CONTACT
Indian Journal of Dental Research   Login   |  Users online: 3149

Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size         

 


 
ORIGINAL RESEARCH Table of Contents   
Year : 2020  |  Volume : 31  |  Issue : 1  |  Page : 145-148
Variable antifungal activity of curcumin against planktonic and biofilm phase of different candida species


1 Department of Oral Medicine and Radiology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India
2 Department of Orthodontics, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India
3 Department of Oral Pathology and Microbiology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India
4 Department of 3Microbiology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India
5 Department of School of Dentistry, University of Queensland, Brisbane, Australia

Correspondence Address:
Veena S Narayanan
Professor and Head, Department of Oral Medicine and Radiology, Coorg Institute of Dental Sciences, Kanjithanda Kushalappa Campus, Maggula, Virajpet - 571 218, Karnataka
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijdr.IJDR_521_17

Rights and Permissions

Objective: To evaluate the in vitro antifungal activity of curcumin against 2 strains of Candida albicans (ATCC 90028 and a clinical isolate – JY strain) and 1 isolate each of 3 nonalbicans – Candida species [Candida parapsilosis (ATCC 22019), C. glabrata (ATCC 90030), and C. dublieniensis (MYA 646)]. Materials and Methods: Planktonic MIC of the 4 Candida species was determined using micro broth dilution assay according to CLSI M27-A3 criteria. The biofilm development and sensitivity assay were performed with the 2 C. albicans strains. Results: Curcumin at high concentrations (0.1–2 mg/mL) was effective in inhibiting planktonic organisms of all the 5 tested Candida strains. The planktonic phase and the biofilm phase of C. albicans ATCC 90028 exhibited similar MIC values for curcumin (0.5 mg/mL). Both curcumin and fluconazole were ineffective against the mature biofilms of JY strain. Conclusion: Our results reported here for the first time, in particular for the biofilm state of C. albicans, imply that curcumin a natural product could be used as a therapeutic alternative to conventional antifungals although further investigations are required to evaluate its potential.


[FULL TEXT] [PDF]*
Print this article     Email this article

 
 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
  Citation Manager
 Access Statistics
  Reader Comments
  Email Alert *
  Add to My List *
 
 

 Article Access Statistics
    Viewed1368    
    Printed16    
    Emailed0    
    PDF Downloaded37    
    Comments [Add]    

Recommend this journal