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| ORIGINAL RESEARCH |
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| Year : 2017 |
Volume
: 28 | Issue : 1 | Page
: 3-9 |
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Expression of E-cadherin and B-cell lymphoma 2 in oral cancer: A ratio-based planning for targeted therapy
Nikita Gulati, Ajit Singh Rathore, Saurabh Juneja, Priyanka Rastogi
Department of Oral and Maxillofacial Pathology and Microbiology, ITS Dental Collge, Ghaziabad, Uttar Pradesh, India
Correspondence Address:
Dr. Nikita Gulati
Department of Oral and Maxiilofacial Pathology and Microbiology, ITS Dental Collge, Murad Nagar, Ghaziabad, Uttar Pradesh - 201 206
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijdr.IJDR_158_16
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Background: Oral cancer is known to be governed by the antiapototic and loss of cell adhesion properties which dictate its progression. Aim: To study the immunexpression of E-cadherin and Bcl-2 in varying TNM stages and histopathological grades of OSCC. Materials and Methods: 11 cases of well differentiated, 10 cases of moderately differentiated and 11 cases of poorly differentiated OSCC were studied immunohistochemically using archival paraffin embedded tissue specimens. Statistical Analysis: Differences between the different variables were analyzed using ANOVA test, Kruskal–Wallis test and post hoc test followed by Bonferroni test. The resulting data was analyzed using SPSS software version 19. Results: The expression of Bcl-2 and E cadherin immunopositivity was associated positively with tumor grade, high T category and Histopathological grades. Conclusions: The results of this study points to the significance of cell proliferation and invasion as a major determinant of prognosis in OSCC. |
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