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| ORIGINAL RESEARCH |
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| Year : 2014 |
Volume
: 25 | Issue : 1 | Page
: 22-27 |
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Periapical tissue reaction to calcium phosphate root canal sealer in porcine model
George M Jacob1, Ajay Kumar2, Jolly Mary Varughese3, NO Varghese4, PR Harikrishna Varma5, Manoj Komath5
1 Department of Conservative Dentistry and Endodontics, PSM College of Dental Science and Research, Akkikavu, Thrissur, Kerala, India
2 Department of Conservative Dentistry and Endodontics, Indira Gandhi Government Dental College, Jammu, Jammu and Kashmir, India
3 Department of Conservative Dentistry and Endodontics, Government Dental College, Trivandrum, Kerala, India
4 Principal and Professor, Dept. of Conservative Dentistry and Endodontics, PMS Dental College, Trivandrum, Kerala, India
5 Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
Correspondence Address:
George M Jacob
Department of Conservative Dentistry and Endodontics, PSM College of Dental Science and Research, Akkikavu, Thrissur, Kerala
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0970-9290.131049
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Background: Calcium phosphate cements (CPC) are a group of biomaterials possessing wide scope of use in various branches of medical science. These materials have been proposed to be highly biocompatible and osteoconductive. This study is based on a newly developed CPC formulation (Chitra-CPC) and is aimed at the evaluation of its biocompatibility through an Endodontic Usage Test in a porcine study model.
Objective: To evaluate the periapical tissue reaction to Chitra-CPC when used as a root canal sealer/filler material in comparison with a resin sealer, AH Plus (Dentsply).
Materials and Methods: The procedure was done on porcine animal model following the ISO 7405 criteria. The material was implanted intentionally into the periapical area of 36 teeth through a root canal procedure carried out in six animals which were divided equally among 1-month and 3-month time periods. Results were based on the histological evaluation of the autopsied specimens after the prescribed time periods.
Results: Mild to moderate periapical tissue reaction was found in Chitra-CPC samples belonging to the 1-month time period, whereas majority of the 3-month CPC samples showed an absence of inflammation. Samples of AH Plus in 1-month period showed severe to moderate inflammation, whereas 3-month AH Plus samples had a mild to moderate inflammation.
Conclusions: Chitra-CPC is a biocompatible material. |
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