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Year : 2011  |  Volume : 22  |  Issue : 1  |  Page : 176-177
Author's reply

Department of Oral Pathology and Microbiology, Meenakshi Ammal Dental College, Alapakkam Main Road, Maduravoyal, Chennai 95, India

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Date of Web Publication25-Apr-2011

How to cite this article:
Kavitha B. Author's reply. Indian J Dent Res 2011;22:176-7

How to cite this URL:
Kavitha B. Author's reply. Indian J Dent Res [serial online] 2011 [cited 2021 Jul 31];22:176-7. Available from:

Reviewing a topic of this magnitude, as you have cited in your comments, [1] was a tough task, and summarizing it in a nutshell was challenging, and thank you for acknowledging our efforts.

It is cited in the second paragraph of our article under, 'Tooth genesis' that 'Tooth development is an excellent example for the reciprocal interaction between ectoderm and the underlying mesenchyme,' which emphasizes the vitality of the interaction between the epithelium and connective tissue. The diagram is only a schematic representation emphasizing the role of the genes in the evolution of the tooth, rather than their localization.

Pax-9 is expressed in dental mesenchyme prior to the first morphological manifestation of odontogenesis by Annette Neubuser, Heiko, Peters et al., [2] is correctly quoted in our article.

"Pax-9 deficient mice --------- lack thymus, parathyroid glands and show absence of teeth," is by Peters, Neubuser et al., [3] and your suggestions on this are accepted.

Msx1 expression correlates with areas of cell proliferation. Msx2 localizes to regions marked for programmed cell death (Mina, Gluhak, Upholt et al.). [4] Our statement that the MSX gene is expressed in undifferentiated multipotential cells that are proliferating or dying, has been misinterpreted.

Barx1 appears in the mesenchyme of the maxillary and mandibular process and Barx2 is observed in the ectodermal lining of these tissues (Jones et al.,). [5] That Barx 2 was expressed in the oral epithelium (instead of ectodermal lining) is an error.

Dlx family comprises six members grouped into pairs (Dlx 1 and 2, Dlx 5 and 6, Dlx 3 and 4), the latter also reported as Dlx7 and Dlx8 as per Morasso et al.[6] We substantiate our statement that the Dlx family of Homeobox genes consists of six members (Dlx 1 - 6).

Trisomy 21, widely known as Down syndrome, is named after th John Langdon Down, who described this syndrome in 1866, and voluminous information is available in all types of media. As the basic literature on Down syndrome has been widely covered in all the write-ups and the incidence of various types of Down syndrome varies with marginal difference in various countries, (Mutton et al. - England, [7] Mokhtar et al. - Egypt, [8] Kava [9] et al. - India), adding references in this case was overlooked. A reference could have been added and the essence of being a Review article could have been justified.

   References Top

1.Ponniah I. Are citations required for a biomedical review article? Indian J Dent Res 2011;22:.174-5.  Back to cited text no. 1
2.Neubüser A, Peters H, Balling R, Martin GR. Martin antagonistic interactions between FGF and BMP signaling pathways: A mechanism for positioning the sites of tooth formation. Cell 1997;90:247-55.  Back to cited text no. 2
3.Peters H, Neubüser A, Kratochwil K, Balling R. Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities Genes Dev 1998;12:2735-47.  Back to cited text no. 3
4.Mina M, Gluhak J, Upholt WB, Kollar EJ, Rogers B. Experimental analysis of Msx-1 and Msx-2 gene expression during chick mandibular morphogenesis. Dev Dyn 1995;202:195-214.   Back to cited text no. 4
5.Jones FS, Kioussi C, Copertino DW, Kallunki P, Holst BD, Edelman GM. Barx2, a new homeobox gene of the Bar class, is expressed in neural and craniofacial structures during development. Proc Natl Acad Sci U S A 1997;94:2632-7.   Back to cited text no. 5
6.Morasso MI, Radoja N. Dlx Genes, p63, and Ectodermal Dysplasias. Birth Defects Res C Embryo Today 2005;75:163-71.   Back to cited text no. 6
7.Mutton D, Alberman E, Hook EB. Cytogenetic and epidemiological findings in Down syndrome, England and Wales 1989 to 1993. National Down Syndrome Cytogenetic Register and the Association of Clinical Cytogeneticists. J Med Genet 1996;33:387-94.  Back to cited text no. 7
8.Mokhtar MM, Abd el-Aziz AM, Nazmy NA, Mahrous HS. Cytogenetic profile of Down syndrome in Alexandria, Egypt. East Mediterr Health J 2003;9:37-44.   Back to cited text no. 8
9.Kava MP, Tullu MS, Muranjan MN, Girisha KM. Down syndrome: Clinical profile from India. Arch Med Res 2004;35:31-5.  Back to cited text no. 9

Correspondence Address:
B Kavitha
Department of Oral Pathology and Microbiology, Meenakshi Ammal Dental College, Alapakkam Main Road, Maduravoyal, Chennai 95
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Source of Support: None, Conflict of Interest: None

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