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REVIEW ARTICLE Table of Contents   
Year : 2008  |  Volume : 19  |  Issue : 1  |  Page : 42-46
Platelet-rich fibrin: Evolution of a second-generation platelet concentrate

V Sunitha Raja1, E Munirathnam Naidu2
1 Department of Periodontics, Meenakshiammal Dental College and Hospital, Alapakkam Road, Maduravoyal, Chennai - 600 095, India
2 Department of Prosthodontics, Meenakshiammal Dental College and Hospital, Alapakkam Road, Maduravoyal, Chennai - 600 095, India

Click here for correspondence address and email

Date of Submission17-Mar-2007
Date of Decision01-Jun-2007
Date of Acceptance12-Jun-2007
 

   Abstract 

Platelet-rich plasma (PRP) is a platelet concentrate that has been used widely to accelerate soft-tissue and hard-tissue healing. The preparation of PRP has been described by several authors. Platelet-rich fibrin (PRF) was first described by Choukroun et al. in France. It has been referred to as a second-generation platelet concentrate, which has been shown to have several advantages over traditionally prepared PRP. Its chief advantages include ease of preparation and lack of biochemical handling of blood, which makes this preparation strictly autologous. This article describes the evolution of this novel platelet concentrate, referred to as PRF.

Keywords: Growth factors, platelets, platelet-rich plasma, wound healing

How to cite this article:
Sunitha Raja V, Munirathnam Naidu E. Platelet-rich fibrin: Evolution of a second-generation platelet concentrate. Indian J Dent Res 2008;19:42-6

How to cite this URL:
Sunitha Raja V, Munirathnam Naidu E. Platelet-rich fibrin: Evolution of a second-generation platelet concentrate. Indian J Dent Res [serial online] 2008 [cited 2021 Jan 18];19:42-6. Available from: https://www.ijdr.in/text.asp?2008/19/1/42/38931
The term tissue engineering was originally coined to denote the construction in the laboratory of a device containing viable cells and biologic mediators (e.g., growth factors and adhesins) in a synthetic or biologic matrix, which could be implanted in patients to facilitate regeneration of particular tissues. The role of tissue oxygenation in wound healing became the focal point in the 1980s. Tissue oxygenation enhances phagocytic and bactericidal ability of host immune cells and supports collagen as well as other protein synthetic events. The importance of growth factors in enhancing wound healing has become the focus of research in the present day. In addition, a link has been established between tissue oxygenation and growth factors. Macrophage stimulation causes the release of angiogenic and other growth factors that support wound healing and resist infection. [1] In general, tissue engineering combines three key elements, namely scaffolds (collagen, bone mineral), signaling molecules (growth factors), and cells (osteoblasts, fibroblasts) [Figure - 1]. Tissue engineering has been redefined presently as the relatively new, highly promising field of reconstructive biology, which draws on the recent advances in medicine and surgery, molecular and cellular biology, polymer chemistry, and physiology.

These principles of tissue engineering have found widespread application in several branches of dentistry, such as periodontics, oral and maxillofacial surgery, and oral implantology. In the field of implant dentistry, the most frequently encountered problems at the implantation site are lack of adequate bone and proximity to anatomic structures, such as the maxillary sinus and the inferior alveolar nerve canal. Advanced surgical procedures that act as an adjunct in dental implants consist of sinus grafting and guided bone regeneration. These procedures are quite predictable when proper surgical protocols are established and followed.

Bone graft materials commonly used for these procedures are demineralized freeze-dried bone allograft (DFDBA) and freeze-dried bone allograft (FDBA). The osteoinductive properties of DFDBA have made it the grafting material of choice as compared to FDBA, xenografts, and alloplasts. However, the osteoinductive potential of DFDBA procured from different bone banks or from different batches of the same bank may vary highly. The bioactivity of DFDBA seems to be dependent on the age of the donor; the younger the donor the more osteoinductive the graft material. [2] This controversy as well as concerns about disease transmission has pushed clinicians toward using xenografts and alloplastic materials. Although these materials are biocompatible and are osteoconductive in nature, clinical outcomes are unpredictable. The problem that arises next is how to improve clinical outcomes by improving the properties of these grafts.

Platelets isolated from peripheral blood are an autologous source of growth factors. When platelets in a concentrated form are added to graft materials, a more predictable outcome is derived. Platelet-rich plasma (PRP) is an easily accessible source of growth factors to support bone- and soft-tissue healing. It is derived by methods that concentrate autologous platelets and is added to surgical wounds or grafts and to other injuries in need of supported or accelerated healing. A blood clot is the center focus of initiating any soft-tissue healing and bone regeneration. In all natural wounds, a blood clot forms and starts the healing process. PRP is a simple strategy to concentrate platelets or enrich natural blood clot, which forms in normal surgical wounds, to initiate a more rapid and complete healing process. A natural blood clot contains 95% red blood cells, 5% platelets, less than 1% white blood cells, and numerous amounts of fibrin strands. A PRP blood clot contains 4% red blood cells, 95% platelets, and 1% white blood cells.

The use of PRP in place of recombinant growth factors has several advantages, in that growth factors obtained from platelets not only have their own specific action on tissues but also interact with other growth factors, resulting in the activation of gene expression and protein production. [3] Therefore, the properties of PRP are based on the production and release of multiple growth and differentiation factors upon platelet activation. These factors are critical in the regulation and stimulation of the wound healing process, and they play an important role in regulating cellular processes such as mitogenesis, chemotaxis, differentiation, and metabolism. [4]


   Platelet Concentrates: Evolution Top


In general, platelet concentrates are blood-derived products used for the prevention and treatment of hemorrhages due to serious thrombopenia of the central origin. The development of platelet concentrates as bioactive surgical additives that are applied locally to promote wound healing stems from the use of fibrin adhesives. Since 1990, medical science has recognized several components in blood, which are a part of the natural healing process; when added to wounded tissues or surgical sites, they have the potential to accelerate healing. Fibrin glue was originally described in 1970 and is formed by polymerizing fibrinogen with thrombin and calcium. It was originally prepared using donor plasma; however, because of the low concentration of fibrinogen in plasma, the stability and quality of fibrin glue were low.

These adhesives can be obtained autologously from the patient or can be obtained commercially (Tisseel, Baxter Healthcare). These products are heat-treated, thus immensely reducing, but not entirely eliminating, the risk of disease transmission. Therefore, the commercially available adhesives constitute an infinitely small risk of disease transmission. PRP is an autologous modification of fibrin glue, which has been described and used in various applications with apparent clinical success. PRP obtained from autologous blood is used to deliver growth factors in high concentrations to the site of bone defect or a region requiring augmentation. [3]

The purpose of this article is to describe the preparation of a novel second-generation platelet concentrate called PRF, which is an improvement over the traditionally prepared PRP. The preparation and use of PRF is prevalent in France, and is not yet popular in the rest of the world for unknown reasons. This article aims to highlight the simplicity of the preparation of PRF as compared to PRP.


   Platelet-Rich Plasma: Preparation Top


Platelets are small, irregularly shaped anuclear cells, 2-4 mm in diameter, which are derived from fragmentation of precursor megakaryocytes. The average life span of a platelet is between 8 and 12 days. Platelets play a fundamental role in hemostasis and are a natural source of growth factors. Growth factors stored in the α-granules of platelets include platelet-derived growth factor, insulin-like growth factor, vascular endothelial growth factor, and transforming growth factor-β [Table - 1]. The release of growth factors is triggered by the activation of platelets, which may be initiated by a variety of substances or stimuli, such as thrombin, calcium chloride, collagen or adenosine 5c-diphosphate. [5] In addition to these growth factors, PRP contains fibrinogen and a number of adhesive glycoproteins that support cell migration.

PRP can be prepared by two techniques. The techniques differ in their technical aspects and are divided into:

  1. General-purpose cell separators
  2. Platelet-concentrating cell separators


General-purpose cell separators require large quantities of blood (450 ml) and generally require to be operated in a hospital setting. Blood is drawn into a collection bag containing citrate-phosphate-dextrose anticoagulant. It is first centrifuged at 5,600 rpm to separate RBCs from platelet-poor plasma (PPP) and PRP. The centrifugation speed is then reduced to 2,400 rpm to get a final separation of about 30 ml of PRP from the RBCs. With this technique, the remaining PPP and RBCs can be returned to the patient's circulation or can be discarded. The ELMD-500 (Medtronic Electromedic, Auto Transfusion System, Parker, CO, USA) cell separator is widely used for this technique.

Platelet-concentrating cell separators are more widely used since this equipment can be accommodated in a dental clinic setup. These technologies permit the procurement of PRP using smaller quantities of blood. Currently, two such systems are approved by FDA and commercially available: Harvest SmartPrep Platelet Concentrate System (HSPCS; Harvest Technologies, Plymouth, MA, USA) and the 3i Platelet Concentrate Collection System (3i PCCS; 3i Implant Innovations, Palm Beach Gardens, FL, USA). Several studies have been performed to compare the efficacy of these systems. [6],[7],[8] Although traditionally a double-spin technique has been used, authors such as Eby et al . [9] have proposed the use of a single spin technique. The preparation and processing of PRP is quite similar in most of the platelet-concentrating systems although the anticoagulant used and the speed and duration of centrifugation may differ with different systems.

  1. Venous blood is drawn into a tube containing an anticoagulant to avoid platelet activation and degranulation.
  2. The first centrifugation is called "soft spin", which allows blood separation into three layers, namely bottom-most RBC layer (55% of total volume), topmost acellular plasma layer called PPP (40% of total volume), and an intermediate PRP layer (5% of total volume) called the "buffy coat".
  3. Using a sterile syringe, the operator transfers PPP, PRP and some RBCs into another tube without an anticoagulant.
  4. This tube will now undergo a second centrifugation, which is longer and faster than the first, called "hard spin". This allows the platelets (PRP) to settle at the bottom of the tube with a very few RBCs, which explains the red tinge of the final PRP preparation. The acellular plasma, PPP (80% of the volume), is found at the top.
  5. Most of the PPP is removed with a syringe and discarded, and the remaining PRP is shaken well.
  6. This PRP is then mixed with bovine thrombin and calcium chloride at the time of application. This results in gelling of the platelet concentrate. Calcium chloride nullifies the effect of the citrate anticoagulant used, and thrombin helps in activating the fibrinogen, which is converted to fibrin and cross-linked. [10]



   Potential Risks of Using PRP Top


Sanchez et al . [11] have elaborated on the potential risks associated with the use of PRP. The preparation of PRP involves the isolation of PRP after which gel formation is accelerated using calcium chloride and bovine thrombin. It has been discovered that the use of bovine thrombin may be associated with the development of antibodies to the factors V, XI and thrombin, resulting in the risk of life-threatening coagulopathies. Bovine thrombin preparations have been shown to contain factor V, which could result in the stimulation of the immune system when challenged with a foreign protein. Other methods for safer preparation of PRP include the utilization of recombinant human thrombin, autologous thrombin or perhaps extra-purified thrombin. Landesberg et al . [12] have suggested that alternative methods of activating PRP need to be studied and made available to the dental community.


   Preparation and Properties of PRF Top


Overcoming the restrictions in the French law related to the reimplantation of blood-derived products, PRF was first developed in France by Choukroun et al . This second-generation platelet concentrate eliminated the risks associated with the use of bovine thrombin. A report of clinical trials comparing the growth factor content of PRF and PRP was presented by Wiltfang et al . at the Second International Symposium on Growth Factors held in May 2005. [13]

Preparation

The advantages of PRF over PRP are its simplified preparation and lack of biochemical handling of the blood. The required quantity of blood is drawn into 10-ml test tubes without an anticoagulant and centrifuged immediately. Blood is centrifuged using a tabletop centrifuge (REMY® Laboratories) for 12 min at 2,700 rpm [Figure - 2].

The resultant product consists of the following three layers:

  • Topmost layer consisting of acellular PPP
  • PRF clot in the middle
  • RBCs at the bottom


Because of the absence of an anticoagulant, blood begins to coagulate as soon as it comes in contact with the glass surface. Therefore, for successful preparation of PRF, speedy blood collection and immediate centrifugation, before the clotting cascade is initiated, is absolutely essential. [14] PRF can be obtained in the form of a membrane by squeezing out the fluids in the fibrin clot.


   Discussion Top


PRF is in the form of a platelet gel and can be used in conjunction with bone grafts, which offers several advantages including promoting wound healing, bone growth and maturation, graft stabilization, wound sealing and hemostasis, and improving the handling properties of graft materials. PRF can also be used as a membrane. Clinical trials suggest that the combination of bone grafts and growth factors contained in PRP and PRF may be suitable to enhance bone density. In an experimental trial, the growth factor content in PRP and PRF aliquots was measured using Elisa kits. The results suggest that the growth factor content (PDGF and TGF-β) was comparable in both. Another experimental study used osteoblast cell cultures to investigate the influence of PRP and PRF on proliferation and differentiation of osteoblasts. In this study, the affinity of osteoblasts to the PRF membrane appeared to be superior. [11]

PRF has many advantages over PRP. It eliminates the redundant process of adding anticoagulant as well as the need to neutralize it. The addition of bovine-derived thrombin to promote conversion of fibrinogen to fibrin in PRP is also eliminated. The elimination of these steps considerably reduces biochemical handling of blood as well as risks associated with the use of bovine-derived thrombin. The conversion of fibrinogen into fibrin takes place slowly with small quantities of physiologically available thrombin present in the blood sample itself. Thus, a physiologic architecture that is very favorable to the healing process is obtained due to this slow polymerization process.

Literature pertaining to PRF is found in French, and the material is being used widely in France. The popularity of this material should increase considering its many advantages. The findings of Wiltfang et al . [13] from a series of clinical trials are encouraging, in that they show improved properties of PRF as compared with PRP. In future, more histologic evaluations from other parts of the world are required to understand the benefits of this second-generation platelet concentrate.

 
   References Top

1.Marx ER. Platelet-rich plasma: A source of multiple autologous growth factors for bone grafts. In : Lynch SE, Genco RJ, Marx RE, editors. Tissue engineering, applications in maxillofacial surgery and periodontics, Quintessence Publishing Co, Inc: Illinois; 1999. p. 71-82.  Back to cited text no. 1    
2.Schwartz Z, Somers A, Mellonig TJ, Carnes DL Jr, Dean DD, Cochran DL, et al . Ability of commercial demineralized freeze-dried bone allograft to induce new bone formation is dependent on donor age but not gender. J Periodontol 1998;69:470-8.  Back to cited text no. 2    
3.Carlson ER. Bone grafting the jaws in the 21 st century: The use of platelet-rich plasma and bone morphogenetic protein. Alpha Omegan 2000;93:26-30.  Back to cited text no. 3  [PUBMED]  
4.Garg AK. The use of platelet-rich plasma to enhance the success of bone grafts around dental implants. Dental Implantol Update 2000;11:17-21.  Back to cited text no. 4    
5.Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85:638-46.  Back to cited text no. 5  [PUBMED]  [FULLTEXT]
6.Appel TR, Potzsch B, Muller J, von Lindern JJ, Bergι SJ, Reich RH. Comparison of three different preparations of platelet concentrates for growth factor enrichment. Clin Oral Implants Res 2002;13:522-8.  Back to cited text no. 6    
7.Weibrich G, Kleis WK. Curasan PRP kit vs. PCCS PRP system: Collection efficiency and platlet counts of two different methods for the preparation of platelet-rich plasma. Clin Oral Implants Res 2002;13:437-43.  Back to cited text no. 7    
8.Weibrich G, Kleis WK, Buch R, Hitzler WE, Hafner G. The Harvest Smart PreP system versus the Friadent-Schutze platelet-rich plasma kit. Clin Oral Implants Res 2003;14:233-9.  Back to cited text no. 8  [PUBMED]  [FULLTEXT]
9.Eby BW. Platelet-rich plasma: Harvesting with a single-spin centrifuge. J Oral Implantol 2002;28:297-301.  Back to cited text no. 9  [PUBMED]  
10.Sonnleitner D, Huemer P, Sullivan DY. A simplified technique for producing platelet-rich plasma and platelet concentrate for intraoral bone grafting techniques: A technical note. Int J Oral Maxillofac Implants 2000;15:879-82.  Back to cited text no. 10  [PUBMED]  
11.Sanchez AR, Sheridan PJ, Kupp LI. Is platelet-rich plasma the perfect enhancement factor? A current review. Int J Oral Maxillofac Implants 2003;18:93-103.  Back to cited text no. 11    
12.Landesberg R, Moses M, Karpatkin M. Risk of using platelet-rich plasma gel. J Oral Maxillofac Surg 1998;56:1116-7.  Back to cited text no. 12  [PUBMED]  [FULLTEXT]
13.Par Wiltfang J, Terheyden H, Gassling V, Acyl A. Platelet rich plasma (PRP) vs. platelet rich fibrin (PRF): Comparison of growth factor content and osteoblast proliferation and differentiation in the cell culture. In: Report of the 2nd International Symposium on growth Factors (SyFac 2005).  Back to cited text no. 13    
14.Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, et al . Platelet-rich fibrin (PRF): A second generation platelet concentrate: Part I: Technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:E37-44.  Back to cited text no. 14    

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Correspondence Address:
V Sunitha Raja
Department of Periodontics, Meenakshiammal Dental College and Hospital, Alapakkam Road, Maduravoyal, Chennai - 600 095
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-9290.38931

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    Tables

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[Pubmed] | [DOI]
38 Platelet-Rich Plasma Versus Tretinoin in Treatment of Striae Distensae
Hend D. Gamil,Samia A. Ibrahim,Howyda M. Ebrahim,Waleed Albalat
Dermatologic Surgery. 2018; 44(5): 697
[Pubmed] | [DOI]
39 Treatment of chronic non-healing ulcers using autologous platelet rich plasma: a case series
Manish Suthar,Saniya Gupta,Suhail Bukhari,Venkatesh Ponemone
Journal of Biomedical Science. 2017; 24(1)
[Pubmed] | [DOI]
40 Surgical management of a large inflammatory periapical lesion with platelet-rich fibrin
NalamN. V. D. Prasanthi,Jyothi Chittem,GurramSamuel Simpsy,GirijaS Sajjan
Journal of Interdisciplinary Dentistry. 2017; 7(2): 76
[Pubmed] | [DOI]
41 Surgical management of a large inflammatory periapical lesion with platelet-rich fibrin
NalamN. V. D. Prasanthi,Jyothi Chittem,GurramSamuel Simpsy,GirijaS Sajjan
Journal of Interdisciplinary Dentistry. 2017; 7(2): 76
[Pubmed] | [DOI]
42 Treatment of chronic non-healing ulcers using autologous platelet rich plasma: a case series
Manish Suthar,Saniya Gupta,Suhail Bukhari,Venkatesh Ponemone
Journal of Biomedical Science. 2017; 24(1)
[Pubmed] | [DOI]
43 Effects of Growth Factors From Platelet-Rich Fibrin on the Bone Regeneration
Jin Kim,Yooseok Ha,Nak Heon Kang
Journal of Craniofacial Surgery. 2017; 28(4): 860
[Pubmed] | [DOI]
44 Effects of Growth Factors From Platelet-Rich Fibrin on the Bone Regeneration
Jin Kim,Yooseok Ha,Nak Heon Kang
Journal of Craniofacial Surgery. 2017; 28(4): 860
[Pubmed] | [DOI]
45 Platelet-rich fibrin or platelet-rich plasma – which one is better? an opinion
Shweta Bansal,Arun Garg,Richa Khurana,Parul Chhabra
Indian Journal of Dental Sciences. 2017; 9(5): 49
[Pubmed] | [DOI]
46 Platelet-rich fibrin or platelet-rich plasma – which one is better? an opinion
Shweta Bansal,Arun Garg,Richa Khurana,Parul Chhabra
Indian Journal of Dental Sciences. 2017; 9(5): 49
[Pubmed] | [DOI]
47 Evaluation of “Autogenous Bioengineered Injectable PRF – Tooth graft” combination (ABIT) in reconstruction of maxillary alveolar ridge defects: CBCT volumetric analysis
Lydia Nabil Melek,Marwan M. El Said
The Saudi Journal for Dental Research. 2017; 8(1-2): 86
[Pubmed] | [DOI]
48 Evaluation of “Autogenous Bioengineered Injectable PRF – Tooth graft” combination (ABIT) in reconstruction of maxillary alveolar ridge defects: CBCT volumetric analysis
Lydia Nabil Melek,Marwan M. El Said
The Saudi Journal for Dental Research. 2017; 8(1-2): 86
[Pubmed] | [DOI]
49 Second-generation Platelet Concentrate (Platelet-rich Fibrin) as a Scaffold in Regenerative Endodontics: A Case Series
Hengameh Bakhtiar,Shahram Esmaeili,Setareh Fakhr Tabatabayi,Mohammad Reza Ellini,Mohammad Hossein Nekoofar,Paul M.H. Dummer
Journal of Endodontics. 2017; 43(3): 401
[Pubmed] | [DOI]
50 Second-generation Platelet Concentrate (Platelet-rich Fibrin) as a Scaffold in Regenerative Endodontics: A Case Series
Hengameh Bakhtiar,Shahram Esmaeili,Setareh Fakhr Tabatabayi,Mohammad Reza Ellini,Mohammad Hossein Nekoofar,Paul M.H. Dummer
Journal of Endodontics. 2017; 43(3): 401
[Pubmed] | [DOI]
51 Endo-restorative management of a type II dens invaginatus in mandibular premolar associated with a large cyst
Swati Borkar,Anita Dhupar,Manjita Parab
Contemporary Clinical Dentistry. 2017; 8(1): 158
[Pubmed] | [DOI]
52 Endo-restorative management of a type II dens invaginatus in mandibular premolar associated with a large cyst
Swati Borkar,Anita Dhupar,Manjita Parab
Contemporary Clinical Dentistry. 2017; 8(1): 158
[Pubmed] | [DOI]
53 Treatment of periodontal intrabony defects using autologous platelet-rich fibrin and titanium platelet-rich fibrin: a randomized, clinical, comparative study
Anirban Chatterjee,Avani R. Pradeep,Vibhuti Garg,Shravanthi Yajamanya,Mohammed M. Ali,V. Sneha Priya
Journal of Investigative and Clinical Dentistry. 2017; 8(3): e12231
[Pubmed] | [DOI]
54 Treatment of periodontal intrabony defects using autologous platelet-rich fibrin and titanium platelet-rich fibrin: a randomized, clinical, comparative study
Anirban Chatterjee,Avani R. Pradeep,Vibhuti Garg,Shravanthi Yajamanya,Mohammed M. Ali,V. Sneha Priya
Journal of Investigative and Clinical Dentistry. 2017; 8(3): e12231
[Pubmed] | [DOI]
55 Evaluating of Platelet-Rich Fibrin in the Treatment of Alveolar Cleft With Iliac Bone Graft By Means of Volumetric Analysis
Nesrin Saruhan,Umit Ertas
Journal of Craniofacial Surgery. 2017; : 1
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56 Natural graft tissues and synthetic biomaterials for periodontal and alveolar bone reconstructive applications: a review
Zeeshan Sheikh,Nader Hamdan,Yuichi Ikeda,Marc Grynpas,Bernhard Ganss,Michael Glogauer
Biomaterials Research. 2017; 21(1)
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57 Apprising the diverse facets of Platelet rich fibrin in surgery through a systematic review
S. Nanditha,Balamanikandasrinivasan Chandrasekaran,Senthilkumar Muthusamy,Kavitha Muthu
International Journal of Surgery. 2017; 46: 186
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58 Apprising the diverse facets of Platelet rich fibrin in surgery through a systematic review
S. Nanditha,Balamanikandasrinivasan Chandrasekaran,Senthilkumar Muthusamy,Kavitha Muthu
International Journal of Surgery. 2017; 46: 186
[Pubmed] | [DOI]
59 Evaluating of Platelet-Rich Fibrin in the Treatment of Alveolar Cleft With Iliac Bone Graft By Means of Volumetric Analysis
Nesrin Saruhan,Umit Ertas
Journal of Craniofacial Surgery. 2017; : 1
[Pubmed] | [DOI]
60 Natural graft tissues and synthetic biomaterials for periodontal and alveolar bone reconstructive applications: a review
Zeeshan Sheikh,Nader Hamdan,Yuichi Ikeda,Marc Grynpas,Bernhard Ganss,Michael Glogauer
Biomaterials Research. 2017; 21(1)
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61 Platelet-rich fibrin: the benefits
Yuvika Raj Kumar,Sujata Mohanty,Mahesh Verma,Raunaq Reet Kaur,Priyanka Bhatia,Varun Raj Kumar,Zainab Chaudhary
British Journal of Oral and Maxillofacial Surgery. 2016; 54(1): 57
[Pubmed] | [DOI]
62 Platelet Rich Fibrin in Periodontal Regeneration
Muthukumaraswamy Arunachalam,Shaju J. Pulikkotil,Nath Sonia
The Open Dentistry Journal. 2016; 10(1): 174
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63 Platelet Rich Fibrin in Periodontal Regeneration
Muthukumaraswamy Arunachalam,Shaju J. Pulikkotil,Nath Sonia
The Open Dentistry Journal. 2016; 10(1): 174
[Pubmed] | [DOI]
64 Does Platelet-Rich Fibrin Enhance Bone Quality and Quantity of Alveolar Cleft Reconstruction?
Hazem Shawky,Sameh Ahmed Seifeldin
The Cleft Palate-Craniofacial Journal. 2016; 53(5): 597
[Pubmed] | [DOI]
65 Autologous Platelet-Rich Plasma for the Treatment of Pattern Hair Loss
Babu Singh,Lynne J. Goldberg
American Journal of Clinical Dermatology. 2016; 17(4): 359
[Pubmed] | [DOI]
66 Platelet-rich fibrin: the benefits
Yuvika Raj Kumar,Sujata Mohanty,Mahesh Verma,Raunaq Reet Kaur,Priyanka Bhatia,Varun Raj Kumar,Zainab Chaudhary
British Journal of Oral and Maxillofacial Surgery. 2016; 54(1): 57
[Pubmed] | [DOI]
67 Autologous Platelet-Rich Plasma for the Treatment of Pattern Hair Loss
Babu Singh,Lynne J. Goldberg
American Journal of Clinical Dermatology. 2016; 17(4): 359
[Pubmed] | [DOI]
68 Does Platelet-Rich Fibrin Enhance Bone Quality and Quantity of Alveolar Cleft Reconstruction?
Hazem Shawky,Sameh Ahmed Seifeldin
The Cleft Palate-Craniofacial Journal. 2016; 53(5): 597
[Pubmed] | [DOI]
69 Platelet-rich fibrin combined with synthetic nanocrystalline hydroxy apatite granules in the management of radicular cyst
K Pradeep,Adarsh Kudva,Vidya Narayanamoorthy,KM Cariappa,MVidya Saraswathi
Nigerian Journal of Clinical Practice. 2016; 19(5): 688
[Pubmed] | [DOI]
70 Platelet-rich fibrin combined with synthetic nanocrystalline hydroxy apatite granules in the management of radicular cyst
K Pradeep,Adarsh Kudva,Vidya Narayanamoorthy,KM Cariappa,MVidya Saraswathi
Nigerian Journal of Clinical Practice. 2016; 19(5): 688
[Pubmed] | [DOI]
71 COMPARATIVE STUDY OF EFFICACY OF PLATELET RICH PLASMA VERSUS MINOXIDIL (5%-10%) IN THE TREATMENT OF ANDROGENETIC ALOPECIA IN MALES
Pawan Kumar Patel,Santosh Kumar Singh,Anil Kumar Gupta,Raj Kumar,Harleen Chhachhi,Rakesh Kumar Patel
Journal of Evolution of Medical and Dental Sciences. 2016; 5(02): 131
[Pubmed] | [DOI]
72 COMPARATIVE STUDY OF EFFICACY OF PLATELET RICH PLASMA VERSUS MINOXIDIL (5%-10%) IN THE TREATMENT OF ANDROGENETIC ALOPECIA IN MALES
Pawan Kumar Patel,Santosh Kumar Singh,Anil Kumar Gupta,Raj Kumar,Harleen Chhachhi,Rakesh Kumar Patel
Journal of Evolution of Medical and Dental Sciences. 2016; 5(02): 131
[Pubmed] | [DOI]
73 Trombositten Zengin Materyaller ve Periodontolojideki Kullanimi
H. Ebru ERDEMIR,Serdar ÖZKAN
Kirikkale Üniversitesi Tip Fakültesi Dergisi. 2016; 16(1): 18
[Pubmed] | [DOI]
74 Trombositten Zengin Materyaller ve Periodontolojideki Kullanimi
H. Ebru ERDEMIR,Serdar ÖZKAN
Kirikkale Üniversitesi Tip Fakültesi Dergisi. 2016; 16(1): 18
[Pubmed] | [DOI]
75 A New Method to Develop Human Dental Pulp Cells and Platelet-rich Fibrin Complex
Xuan He,Wen-Xia Chen,Guifei Ban,Wei Wei,Jun Zhou,Wen-Jin Chen,Xian-Yu Li
Journal of Endodontics. 2016; 42(11): 1633
[Pubmed] | [DOI]
76 Management of maxillary central incisor with an extracanal and periapical cyst using cone-beam computed tomography as a diagnostic aid
Bhavana Chandradhara,A Arun,K Shashikala,N Vanamala
Endodontology. 2016; 28(2): 199
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77 A New Method to Develop Human Dental Pulp Cells and Platelet-rich Fibrin Complex
Xuan He,Wen-Xia Chen,Guifei Ban,Wei Wei,Jun Zhou,Wen-Jin Chen,Xian-Yu Li
Journal of Endodontics. 2016; 42(11): 1633
[Pubmed] | [DOI]
78 A randomized comparative prospective study of platelet-rich plasma, platelet-rich fibrin, and hydroxyapatite as a graft material for mandibular third molar extraction socket healing
ShubhaRanjan Dutta,Deepak Passi,Purnima Singh,Sarang Sharma,Mahinder Singh,Dhirendra Srivastava
National Journal of Maxillofacial Surgery. 2016; 7(1): 45
[Pubmed] | [DOI]
79 A randomized comparative prospective study of platelet-rich plasma, platelet-rich fibrin, and hydroxyapatite as a graft material for mandibular third molar extraction socket healing
ShubhaRanjan Dutta,Deepak Passi,Purnima Singh,Sarang Sharma,Mahinder Singh,Dhirendra Srivastava
National Journal of Maxillofacial Surgery. 2016; 7(1): 45
[Pubmed] | [DOI]
80 Management of maxillary central incisor with an extracanal and periapical cyst using cone-beam computed tomography as a diagnostic aid
Bhavana Chandradhara,A Arun,K Shashikala,N Vanamala
Endodontology. 2016; 28(2): 199
[Pubmed] | [DOI]
81 Comparative release of growth factors from PRP, PRF, and advanced-PRF
Eizaburo Kobayashi,Laura Flückiger,Masako Fujioka-Kobayashi,Kosaku Sawada,Anton Sculean,Benoit Schaller,Richard J. Miron
Clinical Oral Investigations. 2016; 20(9): 2353
[Pubmed] | [DOI]
82 Histopathological Evaluation of Growth Factor-Rich Fibrin Combined with Anorganic Bone Graft Materials and Atelocollagen in a Human Extraction Socket: A Case Report
Tadahiko Utsunomiya,Masato Hayashi,Hiroshi Murakami,Daisuke Nakamoto,Toshiaki Fukushima,Kayo Kuyama
International Journal of Oral-Medical Sciences. 2016; 15(1): 22
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83 Comparative release of growth factors from PRP, PRF, and advanced-PRF
Eizaburo Kobayashi,Laura Flückiger,Masako Fujioka-Kobayashi,Kosaku Sawada,Anton Sculean,Benoit Schaller,Richard J. Miron
Clinical Oral Investigations. 2016; 20(9): 2353
[Pubmed] | [DOI]
84 Histopathological Evaluation of Growth Factor-Rich Fibrin Combined with Anorganic Bone Graft Materials and Atelocollagen in a Human Extraction Socket: A Case Report
Tadahiko Utsunomiya,Masato Hayashi,Hiroshi Murakami,Daisuke Nakamoto,Toshiaki Fukushima,Kayo Kuyama
International Journal of Oral-Medical Sciences. 2016; 15(1): 22
[Pubmed] | [DOI]
85 Oroantral communication repair using bone substitute and platelets rich fibrin
M.H. ElShourbagy,M.M. Hussein,M.S. Khedr,S. Abd Elal
Tanta Dental Journal. 2015; 12(2): 65
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86 Oroantral communication repair using bone substitute and platelets rich fibrin
M.H. ElShourbagy,M.M. Hussein,M.S. Khedr,S. Abd Elal
Tanta Dental Journal. 2015; 12(2): 65
[Pubmed] | [DOI]
87 Treatment of Oral Mucosal Lesions by Scalpel Excision and Platelet-Rich Fibrin Membrane Grafting: A Review of 26 Sites
Himani Pathak,Sujata Mohanty,Aadithya B. Urs,Jitender Dabas
Journal of Oral and Maxillofacial Surgery. 2015; 73(9): 1865
[Pubmed] | [DOI]
88 The effect of platelet-rich fibrin on bone regeneration and angiogenesis in rabbit cranial defects
Sang-Hwa Lee,Sun-Woo Kim,Jae-Il Lee,Hyun-Joong Yoon
Tissue Engineering and Regenerative Medicine. 2015; 12(5): 362
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89 The effect of platelet-rich fibrin on bone regeneration and angiogenesis in rabbit cranial defects
Sang-Hwa Lee,Sun-Woo Kim,Jae-Il Lee,Hyun-Joong Yoon
Tissue Engineering and Regenerative Medicine. 2015; 12(5): 362
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90 Platelet concentrates: Bioengineering dentistry's regenerative dreams
ButchiBabu Kalakonda,UdayKiran Uppada,Shekar Kamisetty,Esther Priyadarshini,Sushma Naag,Abhishek Savirmath
Journal of Dental Research and Review. 2015; 2(2): 86
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91 Quantification of platelets obtained by different centrifugation protocols in SHR rats
João Alberto Yazigi Junior,João Baptista Gomes dos Santos,Bruno Rodrigues Xavier,Marcela Fernandes,Sandra Gomes Valente,Vilnei Mattiolli Leite
Revista Brasileira de Ortopedia (English Edition). 2015; 50(6): 729
[Pubmed] | [DOI]
92 Treatment of infrabony defects with platelet-rich fibrin along with bone graft: Case report
NehaA Patil,SurekhaY Bhedasgaonkar,Janak Kapadia
Journal of the International Clinical Dental Research Organization. 2015; 7(1): 69
[Pubmed] | [DOI]
93 Advancing biomaterials of human origin for tissue engineering
Fa-Ming Chen,Xiaohua Liu
Progress in Polymer Science. 2015;
[Pubmed] | [DOI]
94 Bone neoformation in defects treated with fibrin platelet rich membrane versus collagen membrane: a histomorphometric study in rabbit’s femurs.
Edwin Jonathan Meza,Emil Correa,David Reynaldo Soto,Liz Katty Ríos
Journal Oral Of Research. 2015; 4(1): 32
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95 Quantificação do número de plaquetas a partir de diferentes métodos de centrifugação em ratos da linhagem SHR
João Alberto Yazigi Junior,João Baptista Gomes dos Santos,Bruno Rodrigues Xavier,Marcela Fernandes,Sandra Gomes Valente,Vilnei Mattiolli Leite
Revista Brasileira de Ortopedia. 2015; 50(6): 729
[Pubmed] | [DOI]
96 Quantificação do número de plaquetas a partir de diferentes métodos de centrifugação em ratos da linhagem SHR
João Alberto Yazigi Junior,João Baptista Gomes dos Santos,Bruno Rodrigues Xavier,Marcela Fernandes,Sandra Gomes Valente,Vilnei Mattiolli Leite
Revista Brasileira de Ortopedia. 2015; 50(6): 729
[Pubmed] | [DOI]
97 Quantification of platelets obtained by different centrifugation protocols in SHR rats
João Alberto Yazigi Junior,João Baptista Gomes dos Santos,Bruno Rodrigues Xavier,Marcela Fernandes,Sandra Gomes Valente,Vilnei Mattiolli Leite
Revista Brasileira de Ortopedia (English Edition). 2015; 50(6): 729
[Pubmed] | [DOI]
98 Platelet concentrates: Bioengineering dentistry's regenerative dreams
ButchiBabu Kalakonda,UdayKiran Uppada,Shekar Kamisetty,Esther Priyadarshini,Sushma Naag,Abhishek Savirmath
Journal of Dental Research and Review. 2015; 2(2): 86
[Pubmed] | [DOI]
99 A comparison of efficiency of biopolymer and allograft matrix with autogenous gingival graft used in root coverage procedure
KHameed Fathima,VS Harish
Journal of Pharmacy and Bioallied Sciences. 2015; 7(6): 695
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100 A comparison of efficiency of biopolymer and allograft matrix with autogenous gingival graft used in root coverage procedure
KHameed Fathima,VS Harish
Journal of Pharmacy and Bioallied Sciences. 2015; 7(6): 695
[Pubmed] | [DOI]
101 Effect of osteogenic periosteal distraction by a modified Hyrax device with and without platelet-rich fibrin on bone formation in a rabbit model: A pilot study
P. Pripatnanont,F. Balabid,S. Pongpanich,S. Vongvatcharanon
International Journal of Oral and Maxillofacial Surgery. 2015;
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102 Platelet-rich plasma in androgenic alopecia: Myth or an effective tool
SwapnaS Khatu,YuvrajE More,NeetaR Gokhale,DipaliC Chavhan,Nitin Bendsure
Journal of Cutaneous and Aesthetic Surgery. 2014; 7(2): 107
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103 Clinical effectiveness of combining platelet rich fibrin with alloplastic bone substitute for the management of combined endodontic periodontal lesion
Lata Goyal
Restorative Dentistry & Endodontics. 2014; 39(1): 51
[Pubmed] | [DOI]
104 The bone integration effects of platelet-rich fibrin by removal torque of titanium screw in rabbit tibia
Sung-Am Cho,Byung-Kil Lee,Sang-Hun Park,Jae-Jin Ahn
Platelets. 2014; : 1
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105 Platelet rich fibrin - a novel acumen into regenerative endodontic therapy
Kavita Hotwani,Krishna Sharma
Restorative Dentistry & Endodontics. 2014; 39(1): 1
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106 Effect of concentrated growth factors on beagle periodontal ligament stem cells in vitro
BOHAN YU,ZUOLIN WANG
Molecular Medicine Reports. 2014; 9(1): 235
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107 Effect of concentrated growth factors on beagle periodontal ligament stem cells in vitro
BOHAN YU,ZUOLIN WANG
Molecular Medicine Reports. 2014; 9(1): 235
[Pubmed] | [DOI]
108 Osteoblastic mesenchymal stem cell sheet combined with Choukroun platelet-rich fibrin induces bone formation at an ectopic site
Zhifa Wang,Yanming Weng,Shengjun Lu,Chunlin Zong,Jianyong Qiu,Yanpu Liu,Bin Liu
Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2014; : n/a
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109 The effect of Nanobone® in combination with platelet rich fibrin on bone regeneration following enucleation of large mandibular cysts
R.M. Eldibany,M.M. Shokry
Tanta Dental Journal. 2014;
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110 Platelet-Rich Fibrin Sealant as a Treatment for Complex Perianal Fistulas: A Multicentre Study
F. J. Pérez Lara,A. Moreno Serrano,J. Ulecia Moreno,J. Hernández Carmona,M. Ferrer Marquez,L. Romero Pérez,A. del Rey Moreno,H. Oliva Muñoz
Journal of Gastrointestinal Surgery. 2014;
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111 Improvement in the repair of defects in maxillofacial soft tissue in irradiated minipigs by a mixture of adipose-derived stem cells and platelet-rich fibrin
Yuanzheng Chen,Zhanguo Niu,Yan Xue,Fukang Yuan,Yanjie Fu,Nan Bai
British Journal of Oral and Maxillofacial Surgery. 2014;
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112 Platelet rich fibrin: A new covering material for oral mucosal defects
Sujata Mohanty,Himani Pathak,Jitender Dabas
Journal of Oral Biology and Craniofacial Research. 2014;
[Pubmed] | [DOI]
113 Principles and methods of preparation of platelet-rich plasma: A review and author's perspective
Rachita Dhurat,MS Sukesh
Journal of Cutaneous and Aesthetic Surgery. 2014; 7(4): 189
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114 Cell therapy with bone marrow stromal cells after intracerebral hemorrhage: impact of platelet-rich plasma scaffolds
Jesus Vaquero,Laura Otero,Celia Bonilla,Concepcion Aguayo,Miguel A. Rico,Alicia Rodriguez,Mercedes Zurita
Cytotherapy. 2013; 15(1): 33
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115 The Adjuvant Use of Stromal Vascular Fraction and Platelet-Rich Fibrin for Autologous Adipose Tissue Transplantation
Bin Liu,Xin-Ying Tan,Yan-Pu Liu,Xiao-Fang Xu,Long Li,Hai-Yan Xu,Ran An,Fa-Ming Chen
Tissue Engineering Part C: Methods. 2013; 19(1): 1
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116 The effect of platelet rich fibrin on growth factor levels in urethral repair
Tutku Soyer,Sebnem Ayva,Özlem Boybeyi,Mustafa Kemal Aslan,Murat Çakmak
Journal of Pediatric Surgery. 2013; 48(12): 2545
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117 VITAL PULP THERAPY USING PLATELET-RICH FIBRIN IN AN IMMATURE PERMANENT TOOTH : CASE REPORTS
Ka-Young Lee,Sang-Ho Lee,Nan-Young Lee
THE JOURNAL OF THE KOREAN ACADEMY OF PEDTATRIC DENTISTRY. 2013; 40(2): 120
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118 Platelet rich fibrin: a new paradigm in periodontal regeneration
R. Vinaya Kumar,N. Shubhashini
Cell and Tissue Banking. 2013; 14(3): 453
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119 Effect of autologous platelet-rich plasma on bone regeneration in mandibular fractures
Emad T. Daif
Dental Traumatology. 2013; 29(5): 399
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120 A clinical and radiographic evaluation of the management of periodontal osseous defects with alloplast and platelet rich plasma
Shreya Shetty,Aditi Bose
journal of Regenerative Medicine and Tissue Engineering. 2013; 2(1): 11
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121 Combination of platelet rich fibrin, hydroxyapatite and PRF membrane in the management of large inflammatory periapical lesion
Shivashankar, V. and Johns, D.A. and Vidyanath, S. and Sam, G.
Journal of Conservative Dentistry. 2013; 16(3): 261-264
[Pubmed]
122 The adjuvant use of stromal vascular fraction and platelet-rich fibrin for autologous adipose tissue transplantation
Liu, B. and Tan, X.-Y. and Liu, Y.-P. and Xu, X.-F. and Li, L. and Xu, H.-Y. and An, R. and Chen, F.-M.
Tissue Engineering - Part C: Methods. 2013; 19(1): 1-14
[Pubmed]
123 Cell therapy with bone marrow stromal cells after intracerebral hemorrhage: Impact of platelet-rich plasma scaffolds
Vaquero, J. and Otero, L. and Bonilla, C. and Aguayo, C. and Rico, M.A. and Rodriguez, A. and Zurita, M.
Cytotherapy. 2013; 15(1): 33-43
[Pubmed]
124 Platelet-Rich Fibrin as a Biofuel for Tissue Regeneration
Sujeet Vinayak Khiste,Ritam Naik Tari
ISRN Biomaterials. 2013; 2013: 1
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125 Platelet-Rich Fibrin as a Biofuel for Tissue Regeneration
Sujeet Vinayak Khiste,Ritam Naik Tari
ISRN Biomaterials. 2013; 2013: 1
[Pubmed] | [DOI]
126 Comparative evaluation of biodegradable collagen membrane and platelet-rich fibrin with subepithelial connective tissue graft in the treatment of miller's class i and ii gingival recession defects: A randomized controlled study
Padma Rajan,Satyakrishna Vempati,ChetanS Kumar,SachinK Malagi,Shruti Mohan
Universal Research Journal of Dentistry. 2013; 3(1): 7
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127 Choukroun's platelet rich fibrin in regenerative dentistry
JyotsnaS Patel,SandeepG Patel,Chandrashekhar Kadam
Universal Research Journal of Dentistry. 2013; 3(1): 22
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128 Role of Platelet rich fibrin in wound healing: A critical review
M Jayadev,VRahul Marshal,Balaram Naik,P Karunakar
Journal of Conservative Dentistry. 2013; 16(4): 284
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129 Use of autologous platelet rich fibrin in urethracutaneous fistula repair: preliminary report
Tutku Soyer, Murat Çakmak, Mustafa Kemal Aslan, Mine F. Şenyücel, Üçler Kisa
International Wound Journal. 2012; : no
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130 Use of platelet rich fibrin in a fenestration defect around an implant
R Vijayalakshmi,CS Rajmohan,D Deepalakshmi,G Sivakami
Journal of Indian Society of Periodontology. 2012; 16(1): 108
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131 Platelet Rich Fibrin in the revitalization of tooth with necrotic pulp and open apex
DextonAntony Johns,S Vidyanath,MRamesh Kumar,VasundaraYayathi Shivashankar
Journal of Conservative Dentistry. 2012; 15(4): 395
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132 Platelet Rich Fibrin: A Novel Approach for Osseous Regeneration
Abhishek Singh, Munish Kohli, Nimish Gupta
Journal of Maxillofacial and Oral Surgery. 2012;
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133 Fibrin glue mixed with platelet-rich fibrin as a scaffold seeded with dental bud cells for tooth regeneration
Yang, K.-C. and Wang, C.-H. and Chang, H.-H. and Chan, W.P. and Chi, C.-H. and Kuo, T.-F.
Journal of Tissue Engineering and Regenerative Medicine. 2012; 6(10): 777-785
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134 Platelet-rich fibrin combined with self-setting calcium phosphate cement for repairing jaw defects
Xu, Y.-l. and Wang, D.-l. and Xu, W.-x.
Chinese Journal of Tissue Engineering Research. 2012; 16(29): 5350-5354
[Pubmed]
135 Platelet Rich Fibrin in the revitalization of tooth with necrotic pulp and open apex
Shivashankar, V.Y. and Johns, D.A. and Vidyanath, S. and Ramesh Kumar, M.
Journal of Conservative Dentistry. 2012; 15(4): 395-398
[Pubmed]
136 Correction of postsurgical alveolar ridge defect with vertical alveolar distraction of the onlay block graft
Kocyigit, I.D. and Tuz, H.H. and Alp, Y.E. and Atil, F. and Tekin, U. and Coskunses, F.M.
Journal of Craniofacial Surgery. 2012; 23(5): 1550-1552
[Pubmed]
137 In Search of a consensus terminology in the field of platelet concentrates for surgical use: Platelet-Rich Plasma (PRP), Platelet-Rich Fibrin (PRF), fibrin gel polymerization and leukocytes
Dohan Ehrenfest, D.M. and Bielecki, T. and Mishra, A. and Borzini, P. and Inchingolo, F. and Sammartino, G. and Rasmusson, L. and Everts, P.A.
Current Pharmaceutical Biotechnology. 2012; 13(7): 1131-1137
[Pubmed]
138 Use of platelet rich fibrin in a fenestration defect around an implant
Vijayalakshmi, R. and Rajmohan, C.S. and Deepalakshmi, D. and Sivakami, G.
Journal of Indian Society of Periodontology. 2012; 16(1): 108-112
[Pubmed]
139 Fibrin glue mixed with platelet-rich fibrin as a scaffold seeded with dental bud cells for tooth regeneration
Kai-Chiang Yang,Chun-Hao Wang,Hao-Hueng Chang,Wing P. Chan,Chau-Hwa Chi,Tzong-Fu Kuo
Journal of Tissue Engineering and Regenerative Medicine. 2012; 6(10): 777
[Pubmed] | [DOI]
140 Correction of Postsurgical Alveolar Ridge Defect With Vertical Alveolar Distraction of the Onlay Block Graft
Ismail Doruk Kocyigit,Hakan H. Tuz,Yunus Emre Alp,Fethi Atil,Umut Tekin,Fatih Mehmet Coskunses
Journal of Craniofacial Surgery. 2012; 23(5): 1550
[Pubmed] | [DOI]
141 Platelet-Rich Fibrin withß-Tricalcium Phosphate—A Noval Approach for Bone Augmentation in Chronic Periapical Lesion: A Case Report
K. B. Jayalakshmi,Shipra Agarwal,M. P. Singh,B. T. Vishwanath,Akash Krishna,Rohit Agrawal
Case Reports in Dentistry. 2012; 2012: 1
[Pubmed] | [DOI]
142 Using platelet rich fibrin membrane for bone graft: Case report
V. ???,V. ???,V. Sugwan Kim
Oral Biology Research. 2012; 36(2): 144
[Pubmed] | [DOI]
143 Using platelet rich fibrin membrane for bone graft: Case report
V. ???,V. ???,V. Sugwan Kim
Oral Biology Research. 2012; 36(2): 144
[Pubmed] | [DOI]
144 Platelet Concentrates: Past, Present and Future
Shobha Prakash, Aditi Thakur
Journal of Maxillofacial and Oral Surgery. 2011;
[VIEW] | [DOI]
145 Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction
Luigi Fabrizio Rodella, Gaia Favero, Ramon Boninsegna, Barbara Buffoli, Mauro Labanca, Giorgio Scarì, Luigi Sacco, Tiziano Batani, Rita Rezzani
Microscopy Research and Technique. 2011; 74(8): 772
[VIEW] | [DOI]
146 Periodontal regeneration in deep intrabony periodontal defect using hydroxyapatite particles with platelet rich fibrin membrane–a case report
Pavitra Rastogi, Himani Saini, Rameshwari Singhal, Jaya Dixit
Journal of Oral Biology and Craniofacial Research. 2011; 1(1): 41
[VIEW] | [DOI]
147 Second-generation platelet concentrate (PRF) as a pulpotomy medicament in a permanent molar with pulpitis: a case report
H. Hiremath, S. Saikalyan, S. S. Kulkarni, V. Hiremath
International Endodontic Journal. 2011; : no
[VIEW] | [DOI]
148 Cell therapy for spinal cord repair: Optimization of biologic scaffolds for survival and neural differentiation of human bone marrow stromal cells
Zurita, M., Otero, L., Aguayo, C., Bonilla, C., Ferreira, E., Parajón, A., Vaquero, J.
Cytotherapy. 2010; 12(4): 522-537
[Pubmed]
149 Cell therapy for spinal cord repair: optimization of biologic scaffolds for survival and neural differentiation of human bone marrow stromal cells
Mercedes Zurita,Laura Otero,Concepción Aguayo,Celia Bonilla,Edgar Ferreira,Avelino Parajón,Jesús Vaquero
Cytotherapy. 2010; 12(4): 522
[Pubmed] | [DOI]
150 Platelet-rich fibrin constructs elute higher concentrations of transforming growth factor-β1 and increase tendon cell proliferation over time when compared to blood clots: A comparative in vitro analysis
Visser, L.C. and Arnoczky, S.P. and Caballero, O. and Egerbacher, M.
Veterinary Surgery. 2010; 39(7): 811-817
[Pubmed]
151 Cell therapy for spinal cord repair: Optimization of biologic scaffolds for survival and neural differentiation of human bone marrow stromal cells
Zurita, M. and Otero, L. and Aguayo, C. and Bonilla, C. and Ferreira, E. and Parajón, A. and Vaquero, J.
Cytotherapy. 2010; 12(4): 522-537
[Pubmed]
152 Isolation of platelet granules
Nießen, J., Jedlitschky, G., Greinacher, A., Kroemer, H.K.
Current Protocols in Cell Biology. 2010; Suppl 46: 3351-3354
[Pubmed]
153 In vitro effects of Choukrounæs PRF (platelet-rich fibrin) on human gingival fibroblasts, dermal prekeratinocytes, preadipocytes, and maxillofacial osteoblasts in primary cultures
Dohan Ehrenfest, D.M., Diss, A., Odin, G., Doglioli, P., Hippolyte, M.-P., Charrier, J.-B.
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. 2009; 108(3): 341-352
[Pubmed]
154 In vitro effects of Choukrounæs PRF (platelet-rich fibrin) on human gingival fibroblasts, dermal prekeratinocytes, preadipocytes, and maxillofacial osteoblasts in primary cultures
David M. Dohan Ehrenfest,Antoine Diss,Guillaume Odin,Pierre Doglioli,Marie-Pascale Hippolyte,Jean-Baptiste Charrier
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2009; 108(3): 341
[Pubmed] | [DOI]
155 Slow release of growth factors and thrombospondin-1 in Choukrounæs platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies
EHRENFEST, D.M.D. and DE PEPPO, G.M.
Growth Factors. 2009; 27(1): 63-69
[Pubmed]
156 Platelet-rich-fibrin: A novel root coverage approach
Anilkumar, K. and Geetha, A. and others
Journal of Indian Society of Periodontology. 2009; 13(1): 50
[Pubmed]
157 Slow release of growth factors and thrombospondin-1 in Choukrounæs platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies
David M. Dohan Ehrenfest,Giuseppe M. de Peppo,Pierre Doglioli,Gilberto Sammartino
Growth Factors. 2009; 27(1): 63
[Pubmed] | [DOI]
158 Slow release of growth factors and thrombospondin-1 in Choukrounæs platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies
David M. Dohan Ehrenfest,Giuseppe M. de Peppo,Pierre Doglioli,Gilberto Sammartino
Growth Factors. 2009; 27(1): 63
[Pubmed] | [DOI]



 
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    Abstract
    Platelet Concent...
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    Potential Risks ...
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