Indian Journal of Dental Research

ORIGINAL RESEARCH
Year
: 2019  |  Volume : 30  |  Issue : 2  |  Page : 213--218

Effect of non-surgical periodontal therapy on stress and salivary Chromogranin-A levels: A clinico-biochemical study


Ratika Lihala, Praveen Jayaram, Anirban Chatterjee, Astha Joshi 
 Department of Periodontics and Implantology, The Oxford Dental College and Hospital, Bengaluru, Karnataka, India

Correspondence Address:
Dr. Praveen Jayaram
Department of Periodontics and Implantology, The Oxford Dental College and Hospital, Bengaluru, Karnataka
India

Aim: The aim of the study was to compare chromogranin A (CgA) and stress levels before and after non-surgical periodontal therapy (NSPT). Materials and Methods: A sample of 40 patients in the age range 25–60 years were included in the study and were divided into gingivitis (10 subjects), chronic periodontitis (CP) (15 patients) and aggressive periodontitis (AgP) (15 patients). The patients were asked to complete two sets of stress questionnaires, plaque index, gingival index, probing depth and clinical attachment levels (CAL) were recorded. Salivary samples were taken at baseline and were repeated three months post NSPT. Results: CgA was detected in saliva samples of all the groups. A statistically significant correlation was established between levels of CgA and stress parameters, which was shown to be the highest in AgP (P < 0.001), followed by CP group (P < 0.005) at baseline. Following NSPT, an overall reduction was observed in the levels of CgA, which was correlated with the overall reduction in stress levels for AgP group (P < 0.005) followed by CP group (P < 0.037). Amongst the clinical parameters, CAL showed the strongest correlation with CgA both at baseline and after NSPT (P < 0.001). Conclusion: Stress was directly correlated to the levels of salivary CgA levels, which was the highest for aggressive periodontitis at baseline. NSPT showed a marked improvement in all the parameters. Levels of CgA and CAL showed a significant correlation in both the CP and AgP groups.


How to cite this article:
Lihala R, Jayaram P, Chatterjee A, Joshi A. Effect of non-surgical periodontal therapy on stress and salivary Chromogranin-A levels: A clinico-biochemical study.Indian J Dent Res 2019;30:213-218


How to cite this URL:
Lihala R, Jayaram P, Chatterjee A, Joshi A. Effect of non-surgical periodontal therapy on stress and salivary Chromogranin-A levels: A clinico-biochemical study. Indian J Dent Res [serial online] 2019 [cited 2020 Apr 10 ];30:213-218
Available from: http://www.ijdr.in/article.asp?issn=0970-9290;year=2019;volume=30;issue=2;spage=213;epage=218;aulast=Lihala;type=0