Indian Journal of Dental Research

ORIGINAL RESEARCH
Year
: 2017  |  Volume : 28  |  Issue : 3  |  Page : 248--251

Evaluation of analgesic and anti-inflammatory activity of a combination of tramadol-ibuprofen in experimental animals


Chidambarann Suthakaran, Muniyagounder K Kayalvizhi, Karnam Nithya, Thozhudalangudy AR Raja 
 Department of Pharmacology, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research (Affiliated to Tamil Nadu, Dr. MGR Medical University), Kancheepuram, Tamil Nadu, India

Correspondence Address:
Chidambarann Suthakaran
Department of Pharmacology, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur - 603 319, Kancheepuram, Tamil Nadu
India

Background: Pain is the major concern of patients attending dental clinics, and satisfactory pain relief has always been difficult to achieve. Since the pathophysiology of pain is a complex, central and peripheral nervous system process, combined analgesic regimens with different mechanisms of action as a multimodal approach are becoming popular among the clinicians and dentists. Objectives: The aim of the present study was to evaluate the analgesic and anti-inflammatory activity of ibuprofen and tramadol when used alone or in combination in animal models of pain and inflammation. Animals and Methods: The animals were divided into six groups with six animals in each group. Analgesic activity was assessed by hot plate method in rats and by acetic acid-induced writhing test in mice. Paw edema model in rats after induction with 0.1 mL of 1% carrageenan was used to assess the anti-inflammatory activity. Statistical Analysis: Analysis of variance followed by Tukey's honestly significant difference post hoc test was used for statistical analysis. Results and Conclusion: Combined use of tramadol and ibuprofen provided enhanced analgesic and anti-inflammatory effects in animal models of pain and inflammation.


How to cite this article:
Suthakaran C, Kayalvizhi MK, Nithya K, Raja TA. Evaluation of analgesic and anti-inflammatory activity of a combination of tramadol-ibuprofen in experimental animals.Indian J Dent Res 2017;28:248-251


How to cite this URL:
Suthakaran C, Kayalvizhi MK, Nithya K, Raja TA. Evaluation of analgesic and anti-inflammatory activity of a combination of tramadol-ibuprofen in experimental animals. Indian J Dent Res [serial online] 2017 [cited 2020 Aug 7 ];28:248-251
Available from: http://www.ijdr.in/article.asp?issn=0970-9290;year=2017;volume=28;issue=3;spage=248;epage=251;aulast=Suthakaran;type=0