Indian Journal of Dental Research

ORIGINAL RESEARCH
Year
: 2016  |  Volume : 27  |  Issue : 6  |  Page : 602--608

Estimation of serum lactate dehydrogenase in smokeless tobacco consumers


Abinaya Chari1, P Rajesh1, S Prabhu2 
1 Department of Oral and Maxillofacial Surgery, Chettinad Dental College and Research Institute, Chennai, Tamil Nadu, India
2 Department of Public Health Dentistry, Chettinad Dental College and Research Institute, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. Abinaya Chari
Department of Oral and Maxillofacial Surgery, Chettinad Dental College and Research Institute, Chennai, Tamil Nadu
India

Statement of Problem: Salivary and serum lactate dehydrogenase (LDH) levels have been correlated with potentially malignant lesions. Salivary LDH levels require special testing and can be expensive. The need for a simple and cost-effective analysis tool is essential to detect the oral malignant lesions to benefit rural populations. Aim: The aim of this study is to estimate the serum LDH in patients with oral lesions due to the consumption of smokeless tobacco. Materials and Methods: Thirty-five patients with lesions were selected for this study while twenty patients served as a control. Levels of serum LDH were assessed. Age- and sex-matched controls (n = 10) with no smokeless consumption habit and with the habit but without lesion (n = 10) also had their blood drawn to assess the basal level of LDH. The results were then analyzed through the two-tailed t-test and Chi-square analysis using the SPSS statistics software. Results: The mean LDH value of patients with habit and lesion is 446.8 U/L; the mean LDH value for patients with habit but without the presence of a lesion is 421.2 U/L, and the mean LDH value for patients without a habit or lesion is 269.4 U/L. The patients having the habit of using smokeless tobacco had higher LDH values compared to the other two groups, and it is found to be statistically significant (p < 0.05). Conclusion: Serum LDH values increased in patients with the habit of chewing smokeless tobacco.


How to cite this article:
Chari A, Rajesh P, Prabhu S. Estimation of serum lactate dehydrogenase in smokeless tobacco consumers.Indian J Dent Res 2016;27:602-608


How to cite this URL:
Chari A, Rajesh P, Prabhu S. Estimation of serum lactate dehydrogenase in smokeless tobacco consumers. Indian J Dent Res [serial online] 2016 [cited 2020 Jan 27 ];27:602-608
Available from: http://www.ijdr.in/article.asp?issn=0970-9290;year=2016;volume=27;issue=6;spage=602;epage=608;aulast=Chari;type=0