Year : 2016 | Volume
: 27 | Issue : 6 | Page : 602--608
Estimation of serum lactate dehydrogenase in smokeless tobacco consumers
Abinaya Chari1, P Rajesh1, S Prabhu2
1 Department of Oral and Maxillofacial Surgery, Chettinad Dental College and Research Institute, Chennai, Tamil Nadu, India
2 Department of Public Health Dentistry, Chettinad Dental College and Research Institute, Chennai, Tamil Nadu, India
Statement of Problem: Salivary and serum lactate dehydrogenase (LDH) levels have been correlated with potentially malignant lesions. Salivary LDH levels require special testing and can be expensive. The need for a simple and cost-effective analysis tool is essential to detect the oral malignant lesions to benefit rural populations.
Aim: The aim of this study is to estimate the serum LDH in patients with oral lesions due to the consumption of smokeless tobacco.
Materials and Methods: Thirty-five patients with lesions were selected for this study while twenty patients served as a control. Levels of serum LDH were assessed. Age- and sex-matched controls (n = 10) with no smokeless consumption habit and with the habit but without lesion (n = 10) also had their blood drawn to assess the basal level of LDH. The results were then analyzed through the two-tailed t-test and Chi-square analysis using the SPSS statistics software.
Results: The mean LDH value of patients with habit and lesion is 446.8 U/L; the mean LDH value for patients with habit but without the presence of a lesion is 421.2 U/L, and the mean LDH value for patients without a habit or lesion is 269.4 U/L. The patients having the habit of using smokeless tobacco had higher LDH values compared to the other two groups, and it is found to be statistically significant (p < 0.05).
Conclusion: Serum LDH values increased in patients with the habit of chewing smokeless tobacco.
Dr. Abinaya Chari
Department of Oral and Maxillofacial Surgery, Chettinad Dental College and Research Institute, Chennai, Tamil Nadu
|How to cite this article:|
Chari A, Rajesh P, Prabhu S. Estimation of serum lactate dehydrogenase in smokeless tobacco consumers.Indian J Dent Res 2016;27:602-608
|How to cite this URL:|
Chari A, Rajesh P, Prabhu S. Estimation of serum lactate dehydrogenase in smokeless tobacco consumers. Indian J Dent Res [serial online] 2016 [cited 2020 Jan 27 ];27:602-608
Available from: http://www.ijdr.in/article.asp?issn=0970-9290;year=2016;volume=27;issue=6;spage=602;epage=608;aulast=Chari;type=0