Indian Journal of Dental Research

ORIGINAL RESEARCH
Year
: 2016  |  Volume : 27  |  Issue : 3  |  Page : 230--235

Systemic absorption of 0.1% triamcinolone acetonide as topical application in management of oral lichen planus


Athira Aruna Ramadas1, Renju Jose1, SL Arathy2, Seema Kurup1, Marina Lazar Chandy1, Sreeja P Kumar1 
1 Department of Oral Medicine and Radiology, Amrita School of Dentistry, Kochi, Kerala, India
2 Department of Analytical Toxicology and Forensic Biotechnology, Amrita Institute of Medical Sciences and Research, Kochi, Kerala, India

Correspondence Address:
Athira Aruna Ramadas
Department of Oral Medicine and Radiology, Amrita School of Dentistry, Kochi, Kerala
India

Context: Topical corticosteroids are the treatment of choice for oral lichen planus (OLP) due to its potential anti-inflammatory effect. However, chronic nature of OLP often requires long-term and frequent applications, exposing patients to local and systemic side effects. Aim: To detect the systemic absorption of 0.1% triamcinolone acetonide (TAC) through the oral mucosa of patients with OLP. Subjects and Methods: This was a pilot pharmacokinetic study carried out in the Department of Oral Medicine and Radiology in collaboration with the Department of Toxicology, over 10 months. A total of twenty patients with OLP were included and advised to apply 0.1% TAC 3 times/day for 2 weeks and 2 times/day for next 2 weeks. Blood samples were obtained on the first and second visits and analyzed for triamcinolone using High pressure liquid chromatography (HPLC). Statistical Analysis Used: Paired t-test was done to compare visual analog scale (VAS) score for burning sensation at the first and second visits, statistically significant if P < 0.05. The baseline demographic data were analyzed using descriptive statistics. Results: Paired t-test was done to compare VAS score for burning sensation at the first and second visits, which turned to being statistically significant (P = 0.001). Although HPLC is an established method for the detection of TAC, none of the study populations showed evidence of steroid (TAC) in the blood sample during 4 weeks of treatment duration. Conclusions: 0.1% triamcinolone is a relatively safe drug to be used with no systemic absorption in the standard dose regimen for oral lichen palnus.


How to cite this article:
Ramadas AA, Jose R, Arathy S L, Kurup S, Chandy ML, Kumar SP. Systemic absorption of 0.1% triamcinolone acetonide as topical application in management of oral lichen planus.Indian J Dent Res 2016;27:230-235


How to cite this URL:
Ramadas AA, Jose R, Arathy S L, Kurup S, Chandy ML, Kumar SP. Systemic absorption of 0.1% triamcinolone acetonide as topical application in management of oral lichen planus. Indian J Dent Res [serial online] 2016 [cited 2020 Apr 3 ];27:230-235
Available from: http://www.ijdr.in/article.asp?issn=0970-9290;year=2016;volume=27;issue=3;spage=230;epage=235;aulast=Ramadas;type=0