Year : 2010 | Volume
: 21 | Issue : 3 | Page : 396--401
E-cadherin and CD1a expression in gingival epithelium in periodontal health, disease and post-treatment
Ramya Arun, R Hemalatha, KV Arun, TSS Kumar
Department of Periodontics, Ragas Dental College and Hospital, Uthandi, Chennai, India
Background: Epithelial integrity is important for maintenance of periodontal health. It is not fully known if non-surgical periodontal therapy is capable of recreating the epithelial barrier in its functional state.
Patients and Methods: Sixty-five patients (31 males and 34 females) were included in the study. They were divided into group A (healthy gingiva 16 patients), group B (gingivitis 17 patients), group C (periodontitis 17 patients), and group D (post-treatment 15 patients). Gingival samples were collected and immunohistochemical study was done using E-cadherin and CD1a antibody. Statistical analysis was done using analysis of variance (ANOVA), followed by Tukey-Kramer multiple comparison test for CD1a and Tukey«SQ»s highly significant difference (HSD) test for E-cadherin.
Result: There was a statistically significant difference (P<0.001) in the expression of E-cadherin between healthy (1.846±0.555), gingivitis (1.100±0.994), and periodontitis group (0.700±0.483). Similarly, there was a statistically significant difference (P<0.001) in the expression of CD1a between healthy (75.70±3.09), gingivitis (42.53±3.09), and periodontitis group (29.07±3.08). However, the expression of E-cadherin (1.242±0.653) and CD1a in post-treatment samples (52.18±2.90) was lower with no statistically significant difference when compared to health.
Discussion: The significant reduction in E-cadherin and CD1a levels in periodontal disease when compared to health could possibly be a result of invasion by the periodontopathogens and its subsequent sequel. Although, the post-treatment samples showed significant improvement when compared to disease, the reduction in E-cadherin and CD1a levels when compared to gingival health suggests that the epithelial barrier was not yet fully established in its functional state.
Department of Periodontics, Ragas Dental College and Hospital, Uthandi, Chennai
|How to cite this article:|
Arun R, Hemalatha R, Arun K V, Kumar T. E-cadherin and CD1a expression in gingival epithelium in periodontal health, disease and post-treatment.Indian J Dent Res 2010;21:396-401
|How to cite this URL:|
Arun R, Hemalatha R, Arun K V, Kumar T. E-cadherin and CD1a expression in gingival epithelium in periodontal health, disease and post-treatment. Indian J Dent Res [serial online] 2010 [cited 2020 Apr 10 ];21:396-401
Available from: http://www.ijdr.in/article.asp?issn=0970-9290;year=2010;volume=21;issue=3;spage=396;epage=401;aulast=Arun;type=0