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ORIGINAL RESEARCH Table of Contents   
Year : 2017  |  Volume : 28  |  Issue : 1  |  Page : 3-9
Expression of E-cadherin and B-cell lymphoma 2 in oral cancer: Aratio-based planning for targeted therapy


Department of Oral and Maxillofacial Pathology and Microbiology, ITS Dental Collge, Ghaziabad, Uttar Pradesh, India

Correspondence Address:
Nikita Gulati
Department of Oral and Maxiilofacial Pathology and Microbiology, ITS Dental Collge, Murad Nagar, Ghaziabad, Uttar Pradesh - 201 206
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijdr.IJDR_158_16

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Background: Oral cancer is known to be governed by the antiapototic and loss of cell adhesion properties which dictate its progression. Aim: To study the immunexpression of E-cadherin and Bcl-2 in varying TNM stages and histopathological grades of OSCC. Materials and Methods: 11 cases of well differentiated, 10 cases of moderately differentiated and 11 cases of poorly differentiated OSCC were studied immunohistochemically using archival paraffin embedded tissue specimens. Statistical Analysis: Differences between the different variables were analyzed using ANOVA test, Kruskal–Wallis test and post hoc test followed by Bonferroni test. The resulting data was analyzed using SPSS software version19. Results: The expression of Bcl-2 and E cadherin immunopositivity was associated positively with tumor grade, high T category and Histopathological grades. Conclusions: The results of this study points to the significance of cell proliferation and invasion as a major determinant of prognosis in OSCC.


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