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ORIGINAL RESEARCH Table of Contents   
Year : 2016  |  Volume : 27  |  Issue : 3  |  Page : 230-235
Systemic absorption of 0.1% triamcinolone acetonide as topical application in management of oral lichen planus


1 Department of Oral Medicine and Radiology, Amrita School of Dentistry, Kochi, Kerala, India
2 Department of Analytical Toxicology and Forensic Biotechnology, Amrita Institute of Medical Sciences and Research, Kochi, Kerala, India

Correspondence Address:
Athira Aruna Ramadas
Department of Oral Medicine and Radiology, Amrita School of Dentistry, Kochi, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-9290.186237

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Context: Topical corticosteroids are the treatment of choice for oral lichen planus (OLP) due to its potential anti-inflammatory effect. However, chronic nature of OLP often requires long-term and frequent applications, exposing patients to local and systemic side effects. Aim: To detect the systemic absorption of 0.1% triamcinolone acetonide (TAC) through the oral mucosa of patients with OLP. Subjects and Methods: This was a pilot pharmacokinetic study carried out in the Department of Oral Medicine and Radiology in collaboration with the Department of Toxicology, over 10 months. A total of twenty patients with OLP were included and advised to apply 0.1% TAC 3 times/day for 2 weeks and 2 times/day for next 2 weeks. Blood samples were obtained on the first and second visits and analyzed for triamcinolone using High pressure liquid chromatography (HPLC). Statistical Analysis Used: Paired t-test was done to compare visual analog scale (VAS) score for burning sensation at the first and second visits, statistically significant if P < 0.05. The baseline demographic data were analyzed using descriptive statistics. Results: Paired t-test was done to compare VAS score for burning sensation at the first and second visits, which turned to being statistically significant (P = 0.001). Although HPLC is an established method for the detection of TAC, none of the study populations showed evidence of steroid (TAC) in the blood sample during 4 weeks of treatment duration. Conclusions: 0.1% triamcinolone is a relatively safe drug to be used with no systemic absorption in the standard dose regimen for oral lichen palnus.


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