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ORIGINAL RESEARCH Table of Contents   
Year : 2014  |  Volume : 25  |  Issue : 5  |  Page : 589-593
The effect of Emdogain gel on periodontal regeneration in autogenous transplanted dog's teeth


1 Department of Dentistry, University of Coimbra, Portugal
2 Department of Biophysics and Biomathematics, University of Coimbra, Portugal
3 Department of Pathologic Anatomy, Faculty of Medicine, University of Coimbra, Portugal

Correspondence Address:
Manuel Marques Ferreira
Department of Dentistry, University of Coimbra, Portugal

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-9290.147099

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Aim: The aim of this study was to assess the enamel matrix derivative (EMD) as biomaterial used in autogenous tooth transplantation. Material and Methods: The study consisted of 3 beagle dogs, 5 months old, in which six incisors and six premolars were transplanted to mechanically prepared recipient alveolar sockets. One group of teeth was transplanted to a recipient bed, with EMD in the root surface. The second groups of teeth were transplanted using saline solution in the root surface. Every week, clinical examinations were done. Nine weeks later, the animals were killed and the specimens decalcified and prepared for histological and imunohistochemical analysis. Periodontal healing was evaluated by undertaking histomorphometric investigation and analyzed using the Mann- Whitney test (P = 0.05). Results: In both groups, all the transplanted teeth survived. Between the experimental groups, there was statistically significant difference in the complete healing (P = 0.004). There was statistically significant difference between the treatment group in the occurrence of inflammatory root resorption (P = 0.015) and the occurrence of replacement root resorption (P = 0.041). Conclusions: Emdogain gel used on the surface of transplanted teeth improves the occurrence of complete healing and reduces root resorption.


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