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ORIGINAL RESEARCH Table of Contents   
Year : 2014  |  Volume : 25  |  Issue : 3  |  Page : 357-363
Comparative study of various grading systems in oral squamous cell carcinoma and their value in predicting lymph node metastasis


1 Department of Oral Pathology and Microbiology, The Oxford Dental College, Hospital and Research Centre, Bommanahalli, Bengaluru, Karnataka, India
2 Department of Oral Pathology and Microbiology, Career Dental College, Lucknow,Uttar Pradesh, India

Correspondence Address:
Saleha Jamadar
Department of Oral Pathology and Microbiology, The Oxford Dental College, Hospital and Research Centre, Bommanahalli, Bengaluru, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-9290.138336

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Background: Regional lymph node (LN) metastasis is the single most prognostic factor for oral squamous cell carcinoma (OSCC). An analysis of the prognostic factors is important for predicting prognosis and reducing the mortality in these patients. Objectives: (1) To compare the value of various grading systems in predicting LN metastasis. (2) To evaluate histopathological parameters, which could help in predicting LN metastasis. Materials and Methods: A total of 20 excisional biopsies of OSCCs, were graded according to the four grading systems that is, Broder's, Jakobsson's, Anneroth and Hansen's, and Brynes. We also evaluated various histopathological parameters, which could help in predicting LN metastasis. Results: Grading at the invasive front was most prognostic of LN metastasis. Tumors with total malignancy score ≥8 showed higher incidence of metastases. Conclusion: The histopathological parameters that could help in predicting lymph node metastases (LNM) are keratinization, nuclear pleomorphism (NP), and the pattern of invasion (POI) when assessed at the invasive front. When the whole tumor was considered, histopathological parameters like NP and POI were significant in predicting LNM.


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