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ORIGINAL RESEARCH Table of Contents   
Year : 2013  |  Volume : 24  |  Issue : 5  |  Page : 567-570
Effect of sialagogue on bleeding on probing in Sjögren's syndrome


1 Department of Oral Medicine, Infection and Immunity, Division of Periodontology, Harvard School of Dental Medicine, Harvard University, Boston, MA, USA
2 Department of Oral Medicine and Public Health Research, Tufts University School of Dental Medicine, Boston, MA, USA

Correspondence Address:
Medha Singh
Department of Oral Medicine, Infection and Immunity, Division of Periodontology, Harvard School of Dental Medicine, Harvard University, Boston, MA
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-9290.123371

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Background: Bleeding on probing (BOP) is a frequent observation in patients with Sjögren's syndrome and a sialagogue is routinely prescribed for these patients. Objective: The objective of this study was to evaluate the effect of sialagogue (muscarinic cholinergic agonists) on BOP in patients with Sjögren's syndrome. Materials and Methods: This observational study included 57 subjects. Study population was divided into two groups: Subjects on sialagogue (n = 32) and subjects not on sialagogue due to their side-effects (non-sialagogue, n = 25). The number of sites with BOP was recorded on all teeth. Results: The subjects on sialagogue had a significantly lower mean (standard error) number of sites with BOP 22.97 (2.65) as compared with the non-sialagogue group 46.59 (6.20), P < 0.001. After adjusting for the use of remineralizing rinse the subjects on sialagogue had a significantly lower number of sites with BOP (P < 0.001). Conclusion: In this observational study treatment with sialagogue may prevent BOP in patients with Sjögren's syndrome.


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