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ORIGINAL RESEARCH Table of Contents   
Year : 2012  |  Volume : 23  |  Issue : 5  |  Page : 565-567
Immuno-localization of glucose transporter 4 in healthy human gingiva


1 Department of Periodontics, Faculty of Dental Sciences, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Chennai, India
2 Department of Pathology, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Chennai, India

Correspondence Address:
Suresh Ranga Rao
Department of Periodontics, Faculty of Dental Sciences, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Chennai
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-9290.107327

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Background: The gingiva has been shown to be a target tissue for several hormones. Insulin induces uptake of glucose in the peripheral tissues by upregulating the Glucose transporter 4 expression. Little information is available on the expression of Glucose transporter 4 in human gingiva. Aim: In this regard, a pilot study was performed with the aim of determining the distribution pattern of Glucose transporter 4 in healthy human gingiva. Materials and Methods: Immuno-histochemistry was performed on 10 mounted sections of healthy human gingiva with the primary antibody Glucose Transporter 4 (GLUT 4). Appropriate positive and negative controls were used. Results: Glucose transporter 4 expression was observed in the basal and suprabasal layers of the gingival epithelium and fibroblasts of the gingival connective tissue. Conclusion: This may be the first study to demonstrate the expression of GLUT 4 in the healthy human gingiva. The results of this study raise the possibility that gingiva may serve as a target tissue for insulin action.


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