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Table of Contents   
REVIEW ARTICLE  
Year : 2012  |  Volume : 23  |  Issue : 3  |  Page : 398-406
Biocompatible implant surface treatments


1 Department of Prosthodontics, Rungta College of Dental Sciences and Research Centre, Bhilai, Chattisgarh, India
2 Department of Prosthodontics, Chattisgarh Dental College and Research Institute, Rajnandgaon, Chattisgarh, India

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Date of Submission16-Feb-2010
Date of Decision16-Sep-2010
Date of Acceptance16-Mar-2011
Date of Web Publication11-Oct-2012
 

   Abstract 

Surface plays a crucial role in biological interactions. Surface treatments have been applied to metallic biomaterials in order to improve their wear properties, corrosion resistance, and biocompatibility. A systematic review was performed on studies investigating the effects of implant surface treatments on biocompatibility. We searched the literature using PubMed, electronic databases from 1990 to 2009. Key words such as implant surface topography, surface roughness, surface treatment, surface characteristics, and surface coatings were used. The search was restricted to English language articles published from 1990 to December 2009. Additionally, a manual search in the major dental implant journals was performed. When considering studies, clinical studies were preferred followed by histological human studies, animal studies, and in vitro studies. A total of 115 articles were selected after elimination: clinical studies, 24; human histomorphometric studies, 11; animal histomorphometric studies, 46; in vitro studies, 34. The following observations were made in this review:

  • The focus has shifted from surface roughness to surface chemistry and a combination of chemical manipulations on the porous structure. More investigations are done regarding surface coatings.
  • Bone response to almost all the surface treatments was favorable.
  • Future trend is focused on the development of osteogenic implant surfaces.
Limitation of this study is that we tried to give a broader overview related to implant surface treatments. It does not give any conclusion regarding the best biocompatible implant surface treatment investigated till date. Unfortunately, the eventually selected studies were too heterogeneous for inference of data.

Keywords: Surface roughness, surface treatment, surface coating

How to cite this article:
Pattanaik B, Pawar S, Pattanaik S. Biocompatible implant surface treatments. Indian J Dent Res 2012;23:398-406

How to cite this URL:
Pattanaik B, Pawar S, Pattanaik S. Biocompatible implant surface treatments. Indian J Dent Res [serial online] 2012 [cited 2014 Aug 22];23:398-406. Available from: http://www.ijdr.in/text.asp?2012/23/3/398/102240
Surface plays a crucial role in biological interactions. Characteristics such as surface composition, surface topography, surface roughness, and surface energy affect the mechanical stability of the implant/tissue interface. [1],[2] It was found that cell attachment and proliferation were surface roughness sensitive, and increased as the roughness of Ti-6Al-4V increased. [3] The surface of a biomaterial is the only part in contact with the bioenvironment and is almost always different in morphology and composition from the bulk. Surface treatments have been applied to metallic biomaterials in order to improve their wear properties, corrosion resistance, and biocompatibility. A systematic review was performed on studies investigating the effects of implant surface treatments on bone response and implant fixation.


   Method Top


Studies to be assessed were divided into four categories: clinical studies, histological human studies, animal studies, and in vitro studies. Eligibility criteria were set for each group. Clinical studies were included if (1) they reported a clear outcome of the study and (2) they included at least a 12-month follow-up analysis. Human histological studies were reviewed for the presence of the following: (1) a clear outcome, (2) examination of titanium implants and (3) minimum observation period should be 8 weeks. The following inclusion criteria were formulated for animal studies: (1) the number and type of tested animals should be clearly mentioned in the study; (2) the study should include trials with titanium or titanium alloys, (3) titanium implant should be placed in the bone and (4) minimum observation period should be 8 weeks. For in vivo studies, biological studies were included and interaction with the osteoblasts was reviewed. Investigations related to physical properties like bond strength/ corrosion/ excluded.

The objectives of this review were to find out

  • the different implant surface treatments done to improve the biocompatiblity till date,
  • the bone response to these treatments and
  • the future trends in implant surface treatments.
We searched the literature using PubMed, electronic databases from 1990 to 2009. Key words such as implant surface topography, surface roughness, surface treatment, surface characteristics, and surface coatings were used. The search was restricted to English language articles published from 1990 to December 2009. Additionally, a manual search in the major dental implant journals was performed. The issues from 2001 were searched in following journals: Clinical Oral Implant Research, International Journal of Oral and Maxillofacial Implants, Implant Dentistry, and Journal of Oral Implantology. We tried to give a broader overview related to implant surface treatments.

A total of 115 articles were selected after elimination [Figure 1].
Figure 1: Method of selection of studies

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Implant surface

During the past 40 years, porous metallic orthopedic implants have been used for fixation purposes. In 1968, Hirschhorn was the first to report on the fabrication of a porous metal (a cobalt-chromium alloy) for use as an implant material in 1968. [4] Human osteoblasts can penetrate interconnections over 20 mm in size and colonize and proliferate inside macropores, but the most favorable size is over 40 mm. It assures cell proliferation and differentiation with blood circulation and extracellular liquid exchange. [5] On the basis of clinical results and histological evidence gained from retrieved implants, these porous implants revealed to be biologically fixed by the ingrowth of bony or other tissue. The ingrowth of bone into the porous structure ensures a good transfer of skeletal forces. [6],[7] Reverse (or removal) torque testing showed roughened surfaces are associated with increased interfacial strength. [8],[9],[10] Experiments have also indicated a faster rate and higher degree of bone formation for rougher implants than for implants with smooth surfaces. [11],[12],[13],[14] Implants with the rough-surfaced microthreaded design caused minimal changes in crestal bone levels during healing (stress-free) and under functional loading. [15] Immediate full occlusal loading of partial prostheses supported by microtextured implants in partially edentulous patients demonstrated excellent clinical results. [16] One of the three-dimensional parameters for surface roughness is average surface roughness (Sa) which represents the arithmetic mean of deviations in roughness from the mean plane of analysis. Surfaces with Sa between 1 and 2 μm are included in moderately rough surfaces. Surfaces with Sa greater than 2 μm are "rough" surfaces. [17] Surfaces with intermediate roughness (Sa 1.5 μm) had higher bone-implant contact indices. [18]

Methods for fabricating porous surface can be classified as either additive or ablative.

Ablative method

Ablative methods remove material from the surface. Common methods for ablating dental implant surfaces include grit blasting, [19],[20],[21] acid etching, [22] grit blasting followed by acid etching, [23],[24] anodizing, [25],[26],[27] shot peening and laser peening. [28],[29]

Grit blasting

Ceramic particles are projected through a nozzle at high velocity by means of compressed air. Depending on the size of the ceramic particles, different surface roughnesses can be produced on titanium implants. The blasting material should be chemically stable, biocompatible and should not hamper the osseointegration of the titanium implants. Various ceramic particles have been used, such as alumina, titanium oxide and calcium phosphate particles. [19],[20] Contamination could negatively influence titanium's biocompatibility. [30]

Alumina: Alumina (Al 2 O 3 ) is frequently used as a blasting material [19] and produces surface roughness varying with the size of 25, 50, and 75 mm of the blasting media. However, the blasting material is often embedded into the implant surface and the residue remains even after ultrasonic cleaning, acid passivation and sterilization. Alumina is insoluble in acid and is thus hard to remove from the titanium surface. In some cases, these particles have been released into the surrounding tissues and have interfered with the osseointegration of the implants.

Titanium oxide: Titanium oxide is also used for blasting titanium dental implants. Titanium oxide particles with an average size of 25 μm produce a moderately rough surface in the 1-2 μm range on dental implants. An experimental study using micro-implants in humans has shown a significant improvement for bone-to-implant contact (BIC) for the TiO 2 -blasted implants in comparison with machined surfaces. [21] Other experimental studies confirmed the increase in BIC for titanium grit-blasted surfaces. [31],[32],[33] Titanium dioxide-blasted implants offer predictable long-term results as supports for fixed prostheses in both the maxilla and mandible, [33] e.g. TiOblastTM (AstraTech Dental, Mölndal, Sweden), Neoss implant (Neoss, Harrogate, UK).

Calcium phosphates: Calcium phosphates such as hydroxyapatite (HA), beta-tricalcium phosphate and mixtures have been considered useful blasting materials. [20] These are biocompatible, osteoconductive and resorbable materials leading to a clean, textured, pure titanium surface. Experimental studies have demonstrated a higher BIC with these surfaces when compared to machined surfaces. [34],[35] Calcium phosphates-blasted implants offer predictable long-term results as supports for fixed prostheses in both the maxilla and mandible. [36] Histologic analysis revealed that the mean bone-to-implant apposition was significantly greater with calcium phosphate-blasted surfaces compared to machined surfaces, regardless of bone quality, [37] e.g. Zimmer Dental's MTX, Nanotite (Biomet 3i, Palm Beach Gardens, FL, USA), Ospol (Malmφ, Sweden).

Roughening of implants by acid etching

Etching with strong acids such as HCl, H 2 SO 4 , HNO 3 and HF is another method for roughening titanium dental implants. [38],[39],[40] Acid etching produces micropits on titanium surfaces, with sizes ranging from 0.5 to 2 μm in diameter. Acid etching with 1% hydrofluoric acid/30% nitric acid after sandblasting eliminates residual alumina particles. [38] High temperature acid etching produces a homogeneous microporous surface. It was reported that the Ti modifications which shift very suddenly from a hydrophobic (high surface contact angle) to a hydrophilic (low surface contact angle) state adsorbed the highest amount of immunologically assayed fibronectin. [41] Chemical modification of the sandblasted and acid-etched (SLA) surface positively influences the osseointegration and decreases the healing time. [42],[43],[44],[45],[46],[47] Implants with the SLA surface can be restored in patients in approximately half of the time of conventional healing periods. [48] SLA endosseous surface can be restored after approximately 6 weeks of healing with a high predictability of success. [49],[50],[51] Osteotite Implant System (Implant Innovations Inc 3i, Palm Beach Gardens, FL, USA), ANKYLOS, XiVE, FRIALIT implants (DENTSPLY Friadent), and The Straumann (Basel, Switzerland) are grit-blasted and high-temperature etched surfaces. The increased roughness compared with turned implants, combined with possible microstructural changes in the oxide resulting from the acid treatment produces good cell and tissue responses, such as greater bone-implant contact. [39] Titanium is very reactive to fluoride ions, forming soluble TiF4 species. This chemical treatment of the titanium created both a surface roughness and fluoride incorporation favorable to the osseointegration of dental implants, e.g. Astra Osseospeed implant (AstraTech Dental, Mölndal, Sweden).

Roughening of implants by anodization

Micro or nanoporous surfaces may also be produced by potentiostatic or galvanostatic anodization of titanium in strong acids H 2 SO 4 , H 3 PO 4 , HNO 3 , HF at high current density (200 A/m 2 ) or potential (100 V). The result of the anodization is to thicken the oxide layer to more than 1000 nm on titanium. When strong acids are used in an electrolyte solution, the oxide layer will be dissolved along current convection lines and thickened in other regions. The dissolution of the oxide layer along the current convection lines creates micro or nanopores on the titanium surface. [25],[26] Anodization produces modifications in the microstructure and the crystallinity of the titanium oxide layer. [27] The anodization process is rather complex and depends on various parameters such as current density, concentration of acids, composition and electrolyte temperature. It was found that (i) with increasing voltage, the roughness (from 0.3 to 2.5 μm) and thickness (from 1 μm to 15 μm) of the film increased and (ii) the TiO2 phase changed from anatase to rutile, a considerable improvement in their osseointegration capacity as compared to the unmodified CpTi implants. [52] Significantly higher bone response for anodic oxidized titanium implants was observed than for implants with a turned surface. [53],[54]

One study concluded that oxide properties of titanium implants, which include oxide thickness, micropore configurations and crystal structures, greatly influence the bone tissue response in the evaluation of removal torque values, [55] e.g. Nobel Biocare (TiUnite) Zurich, Switzerland.

Roughening of implants by shot peening and laser peening

Shot peening [28] (which is a similar technique to sandblasting, but has more controlled peening power, intensity, and direction) is a process in which the surface is bombarded with small spherical media called shot. Each piece of shot striking the material acts as a tiny hammer, imparting to the surface small indentations or dimples. [28] The laser peening technology is recently developed, contamination-free peening method. [29] Before treatment, the surface is covered with a protective layer (paint or tape). High-intensity (5-15 GW/cm 2 ) nanosecond pulses (10-30 ns) of laser light beam (3-5 mm width) strike the protective layer. Implants demonstrated a deep and regular honeycomb pattern with small pores, [29] e.g. laserlok Surface (Bio horizon, Birmingham, Alabama).

Additive Method

A number of processes have been applied to produce porous titanium and titanium alloy implants by additive method. Generally, these different methods can be divided into three categories as follows.

  1. Porous coatings can be produced by sintering uniformly sized beads or fibers onto the substrate by isostatic pressing or loose packing. [15] These methods are associated with numerous drawbacks. These include: a low porosity (generally less than 50%), uncontrollable pore size (which is determined by the size of the particles) and incomplete interconnections between the pores.
  2. Porous coatings can also be fabricated by mixing titanium powder with an organic spacer holder. This mixture is applied to the surface of the implant and becomes permanently affixed under controlled conditions of temperature and pressure. The organic material is subsequently removed, leaving a porous, metallic coating on the implant surface. The problem with this method is that it is difficult to control the interconnectivity of the pores, some of which remain closed.
  3. The third methodological category includes titanium plasma sprayed (TPS) surfaces. To prepare these surfaces, titanium particles are heated to a nearly molten state and sprayed at the substrate via inert gas plasmas. The softened particles "splat" on the surface and rapidly solidify. The resultant surface is quite irregular and rough. This increased surface texture, with relatively greater void volume into which bone can grow, results in higher removal torque value. The Sa depends on the manufacturer but can be up to 6 μm. [56] The drawbacks of this method are the poor interconnectivity of the pores and a small pore size. Several studies, however, have shown cause for concern with TPS implants. For example, titanium particles have been detected in peri-implant tissues. [57] TPS surfaces have also been associated with increased mobility and higher incidence of peri-implant inflammation and recession, [58] e.g. PITT-EASY (Sybron Implant Solutions GmbH, Germany).
Osteoconductive calcium phosphate coatings on dental implants

Metal implants have been coated with layers of calcium phosphates mainly composed of HA. Following implantation, the release of calcium phosphate into the peri-implant region increases the saturation of body fluids and precipitates a biological apatite onto the surface of the implant. [59] This layer of biological apatite might contain endogenous proteins and serve as a matrix for osteogenic cell attachment and growth. [60] Calcium phosphate coated surfaces adsorb twice as much albumin as the titanium surfaces. [61] HA coating is an effective method for improving bone formation and ingrowth in the porous implants. [62],[63],[64] One study found that the osteoblast amount and activity on the surfaces containing Ca are higher than those on the surface containing sole P ions. [65]

Different methods have been developed to coat metal implants: plasma spraying, [66],[67] sputter deposition, [68],[69],[70] radiofrequent (RF) magnetron sputtering technique, [71],[72],[73],[74],[75] sol-gel coating, [76],[77],[78],[79] pulsed laser deposition (PLD), [80],[81],[82] electrophoretic deposition, [83],[84] or biomimetic precipitation, [85],[86],[87] and dipping method. [88]

Metal implants have been coated (by plasma spraying or other methodologies) with layers of HA, [89] calcium phosphate [90] or mixtures of the two. [91] These coated implants are, moreover, characterized by a rough surface profile, which further improves osseoconduction and osseointegration. By coating implants with HA such as by plasma spraying, both the roughness and surface chemistry are altered. The roughness increases to Sa 5.8 μm [56] and the surface chemistry is dramatically changed from TIO 2 to a bone-like ceramic with the potential for chemically bonding to bone. Unfortunately, the properties of commercial coatings can be quite variable. During plasma splaying, HA can be transformed to other foams of calcium phosphate, with different crystalline structures, such as β-tricalcium phosphate. There are reports [92],[93],[94],[95],[96] documenting the clinical success of dental implants coated with calcium phosphate. In Bicon Implant System (Boston, USA), Star lock implants (Park Dental Research Corp, USA), Osstem (South Korea) surfaces are HA coated. There is a report on fluoridated HA coating where fluoride was incorporated. [97]

The plasma spray method employs extremely high temperatures (10,000-12,000°C) during the coating process. Unfortunately, it results in potentially serious problems including (i) an alteration of structure, (ii) formation of apatite with extremely high crystallinity, and (iii) long-term dissolution and the accompanying debonding of the coating layer. Studies [97],[98],[99] have observed failures with HA-coated implants. Therefore, in recent coating techniques like RF sputtering technique, [71],[72],[73] electrophoretic deposition, [83],[84] sol-gel coating [76],[77],[78],[79] and biomimetic precipitation, [85],[86],[87] the calcium phosphate coatings are thin and there is increase in bond strength between calcium phosphate and the implant surfaces. The surface treatment method affects the type of TiO2 layer formed (anatase or rutile) and affects apatite deposition and adhesion on the Ti surface. [100] Electrochemical deposition is more efficient and less sensitive to the conditions of the Ti surfaces compared to the biomimetic depositions; however, the electrochemical deposition produces less uniform and thinner coating layers on the inner pore surfaces compared with the biomimetic deposition. [101] The biomimetic coating technique involves the nucleation and growth of bone-like crystals upon a pretreated substrate by immersing this in a supersaturated solution of calcium phosphate under physiological conditions of temperature (37°C) and pH (7.4). The method, originally developed by Kokubo, [85] has since undergone improvement and refinement by several groups of investigators. [86],[87] The same principle would also apply to the incorporation of other drugs into such implants. By this means, implants can be osteoinductive (growth factors) as well as osteoconductive (calcium phosphate layer). Some recent coating techniques investigated are listed in [Table 1].
Table 1: Some recent coating techniques investigated

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   Future Trends in Dental Implant Surfaces Top


The surface of titanium dental implants may be coated with bone-stimulating agents such as growth factors in order to enhance the bone healing process locally. Some of the most promising candidates for this purpose are bone morphogenetic proteins (BMPs), transforming growth factor (TGF)-1, platelet-derived growth factor (PDGF) and insulin-like growth factor (IGF)-1 and -2, fibroblast growth factor-fibronectin (FGF-FN) fusion protein. [110] BMPs incorporated into dental implants have been obtained from by various methods. [111],[112],[113],[114] Titanium alloy implants bearing a fine, dense, amorphous layer of calcium phosphate were immersed in a supersaturated solution of calcium phosphate containing growth factors such as BMP-2 for 48 h under physiological conditions of temperature (37°C) and pH (7.4). The implants became coated with a crystalline latticework of the inorganic components into which BMP-2 was incorporated. Although BMP-2 is itself osteoinductive, its osteogenic potency was markedly enhanced after incorporation into biomimetic calcium phosphate coatings.

The surface of implants could also be loaded with molecules controlling the bone remodeling process. Incorporation of bone antiresorptive drugs, such as biphosphonates, might be very relevant in compromised clinical cases, e.g. resorbed alveolar ridges. Other experimental studies using plasma-sprayed HA-coated dental implants immersed in pamidronate or zoledronate demonstrated a significant increase in bone contact area. [115],[116],[117] The main problem lies in the grafting and sustained release of antiresorptive drugs on the titanium implant surface. Mixing antibiotics with polymethylmetaacrylate (PMMA) bone cements has been shown to provide adequate local antibiotic concentrations for extended periods of time. [118],[119]


   Summary Top


Quest for excellence has led to innovative materials and techniques. Concepts are gradually changing based on evidence. In early days of implant dentistry, smooth surface titanium implants were used. Porous surface implants were developed by additive and ablative methods. The continuing search for "osseogenic" implants is leading to surface modifications involving biological molecules. Powerful cytokines and growth factors are incorporated to obtain the desired cell and tissue responses. Limitation of this study is that we have tried to give a broader overview related to implant surface treatments. It does not give any conclusion regarding the best biocompatible implant surface treatment investigated till date. Unfortunately, the eventually selected studies were too heterogeneous for inference of data.

The following observations were made from this review:

  • The focus has shifted from surface roughness to surface chemistry and a combination of chemical manipulations on the porous structure. More investigations are done regarding surface coatings.
  • Almost all the study comparisons were done with machined smooth implants and there were a few studies comparing different new methods of surface modifications.
  • In animal study models, maximum studies investigated only, the bone response and very few studies were investigated with loaded implants.
  • Careful controlled clinical trials comparing different recent surface modifications are needed to evaluate clinical efficacy.
  • Bone response to almost all the surface treatments was favorable.
  • Future trend is focused on the development of osteogenic implant surfaces.
It can be said that the key message in this study is that in compromised conditions like in poor bone quality, calcium phosphate coated implants can be useful. Rough surface implants are more osteoconductive than smooth surface implants.

 
   References Top

1.Smith DC, Pilliar RM, Chernecky R. Dental implant materials,I:Some effects of preparative procesdures on surface topography. JBioMed Mater Res 1991;25:1045-68.  Back to cited text no. 1
[PUBMED]    
2.Kieswetter K, Schwartz Z, Dean DD, Boyan BD. The role of implant surface characteristics in the healing of bone. Crit Rev Oral Biol Med 1996;7:329-45.  Back to cited text no. 2
[PUBMED]    
3.Deligianni DD, Katsala N, Ladas S, Sotiropoulou D, Amedee J, Missirlis YF. Effect of surface roughness of the titanium alloy Ti-6Al-4V on human bone marrow cell response and on protein adsorption. Biomaterials 2001;22:1241-51.   Back to cited text no. 3
[PUBMED]    
4.Pilliar RM. Overview of surface variability of metallic endosseous dental implants, textured and porous surface-structured designs. Implant Dent 1998;7:305-14.  Back to cited text no. 4
[PUBMED]    
5.Lu Jx, Flautre B, Anselme K, Hardouin P, Gallur A. Role of interconnections in porous bioceramics on bone recolonizationIn vitro and In vivo. J Mater Sci Mater Med 1999;10:111-20.  Back to cited text no. 5
    
6.Robertson DM, Pierre L, Chahal R. Preliminary observations of bone in growth into porous materials. J Biomed Mater Res 1976;10:335-44.  Back to cited text no. 6
[PUBMED]    
7.Bobyn JD, Pilliar RM, Cameron HU, Weatherly GC, Kent GM. The effect of porous surface configuration on the tensile strength of fixation of implants by bone growth. ClinOrthop 1980;149:291-8.  Back to cited text no. 7
[PUBMED]    
8.Piattelli A, Manzon L, Scarano A, Paolantonio M, Piattelli M. Histologic and histomorphometric bone response to machined and sandblasted titanium implants:An experimental study in rabbits. Int J Oral Maxillofac Implants 1998;13:805-10.  Back to cited text no. 8
    
9.Buser D, Schenk RK, Steinemann S, Fiorellini JP, Fox CH, Stich H. Influence of surface characteristics on bone integration of titanium implants:A histomorphometric study in miniature pigs. J Biomed Mater Res 1991;25:889-902.  Back to cited text no. 9
[PUBMED]    
10.Bowers KT, Keller JC, Randolph BA, Wick DG, Michaels CM. Optimization of surface micromorphology for enhanced osteoblast responses invitro. Int J Oral Maxillofac Implants 1992;7:302-10.  Back to cited text no. 10
[PUBMED]    
11.Abrahamsson I, Berglundh T, Linder E, Lang NP, Lindhe J. Early bone formation adjacent to rough and turned endosseous implant surfaces:An experimental study in the dog. Clin Oral Implants Res 2004;15:381-92.  Back to cited text no. 11
[PUBMED]    
12.Aparicio C, Gil FJ, Planell JA, Engel E. Human-osteoblast proliferation and differentiation on grit-blasted and bioactive titanium for dental applications. J Mater Sci Mater Med 2002;13:1105-11.  Back to cited text no. 12
[PUBMED]    
13.Boyan BD, Lossdörfer S, Wang L, Zhao G, Lohmann CH, Cochran DL,et al. Osteoblasts generate an osteogenic microenvironment when grown on surfaces with rough microtopographies. Eur Cell Mater2003;6:22-7.  Back to cited text no. 13
    
14.Lossdörfer S, Schwartz Z, Wang L, Lohmann CH, Turner JD, Wieland M, Cochran DL, Boyan BD. Microrough implant surface topographies increase osteogenesis by reducing osteoclast formation and activity. J Biomed Mater Res A 2004;70:361-9.  Back to cited text no. 14
    
15.Nickenig HJ, Wichmann M, Schlegel KA, Nkenke E, Eitner S. Radiographic evaluation of marginal bone levels adjacent to parallel-screw cylinder machined-neck implants and rough-surfaced microthreaded implants using digitized panoramic radiographs. Clin Oral Implants Res 2009;20:550-4.  Back to cited text no. 15
    
16.Cannizzaro G, Leone M. Restoration of partially edentulous patients using dental implants with a microtextured surface:A prospective comparison of delayed and immediate full occlusal loading. Int J Oral Maxillofac Implants 2003;18:512-22.  Back to cited text no. 16
    
17.Wennerberg A, Albrektsson T. Suggested guidelines for the topographic evaluation of implant surfaces. Int J Oral Maxillofac Implants 2000;15:331-4.  Back to cited text no. 17
    
18.Wennerberg A, Albrektsson T, Andersson B, Krol JJ. A histomorphometric and removal torque study of screw-shaped titanium implants with three different surface topographies. Clin Oral Implants Res 1995;6:24-30.  Back to cited text no. 18
    
19.Wennerberg A, Albrektsson T, Andersson B. Bone tissue response to commercially pure titanium implants blasted with fine and course particles of aluminium oxide. Int J Oral Maxillofac Implants 1996;11:38-45.  Back to cited text no. 19
    
20.Citeau A, Guicheux J, Vinatier C, Layrolle P, Nguyen TP, Pilet P, et al. In vitro biological effects of titanium rough surface obtained by calcium phosphate grid blasting. Biomaterials 2005;26:157-65.  Back to cited text no. 20
    
21.Ivanoff CJ, Hallgren C, Widmark G, Sennerby L, Wennerberg A. Histologic evaluation of the bone integration of TiO(2) blasted and turned titanium microimplants in humans. Clin Oral Implants Res 2001;12:128-34.  Back to cited text no. 21
    
22.Klokkevold PR, Johnson P, Dadgostari S, Caputo A, Davies JE, Nishimura RD. Early endosseous integration enhanced by dual acid etching of titanium:A torque removal study in the rabbit. Clin Oral Implants Res 2001;12:350-7.  Back to cited text no. 22
    
23.Cochran DL, Nummikoski PV, Higginbottom FL, Hermann JS, Makins SR, Buser D. Evaluation of an endosseous titanium implant with sandblasted and acid-etched surface in the canine mandible:Radiographic results. Clin Oral Implants Res 1996;7:240-5.  Back to cited text no. 23
    
24.Buser D, Broggini N, Wieland M, Schenk RK, Denzer AJ, Cochran DL, et al. Enhanced bone apposition to a chemically modified SLA titanium surface. J Dent Res 2004;83:529-33.  Back to cited text no. 24
    
25.Sul YT, Johansson CB, Jeong Y, Wennerberg A, Albrektsson T. Oxidized implants and their influence on the bone response. J Mater Sci Mater Med 2001;12:1025-31.  Back to cited text no. 25
    
26.Huang YH, Xiropaidis AV, Sorensen RG, Albandar JM. Bone formation at titanium porous oxide (TiUnite) oral implants in type IV bone. Clin Oral Implants Res 2005;16:105-11.  Back to cited text no. 26
    
27.Sul YT, Johansson CB, Albrektsson T. Qualitative and quantitative observations of bone tissue reactions to anodized implants. Biomaterials 2002;23:1809-17.  Back to cited text no. 27
    
28.Pypen CM, Plenk H Jr, Ebel MF, Svagera R, Wernisch J. Characterization of microblasted and reactive ion etched surfaces on the commercially pure metals niobium, tantalum and titanium. J Mater Sci Mater Med 1997;8:781-4.  Back to cited text no. 28
    
29.Gaggl A, Schultes G, Müller WD, Kärcher H. Scanning electron microscopical analysis of laser-treated titanium implant surfaces: A comparative study. Biomaterials 2000;21:1067-73.  Back to cited text no. 29
    
30.Miyakawa O, Watanabe K, Okawa S, Kanatani M, Nakano S, Kobayashi M. Surface contamination of titanium by abrading treatment. Dent Mater J 1996;15:11-21.  Back to cited text no. 30
    
31.Rasmusson L, Kahnberg KE, Tan A. Effects of implant design and surface on bone regeneration and implant stability:An experimental study in the dog mandible. Clin Implant Dent Relat Res 2001;3:2-8.  Back to cited text no. 31
    
32.Gotfredsen K, Karlsson U. A prospective 5-year study of fixed partial prostheses supported by implants with machined and TiO2-blasted surface. J Prosthodont 2001;10:2-7.  Back to cited text no. 32
    
33.Rasmusson L, Roos J, Bystedt H. A 10-year follow-up study of titanium dioxide-blasted implants. Clin Implant Dent Relat Res 2005;7:36-42.  Back to cited text no. 33
    
34.Novaes AB Jr, Souza SL, de Oliveira PT, Souza AM. Histomorphometric analysis of the bone-implant contact obtained with 4 different implant surface treatments placed side by side in the dog mandible. Int J Oral Maxillofac Implants 2002;17:377-83.  Back to cited text no. 34
    
35.Piattelli M, Scarano A, Paolantonio M, Iezzi G, Petrone G, Piattelli A. Bone response to machined and resorbable blast material titanium implants:An experimental study in rabbits. J Oral Implantol 2002;28:2-8.  Back to cited text no. 35
    
36.Gonshor A, Goveia G, Sotirakis E. A prospective, multicenter, 4-year study of the ACE Surgical resorbable blast media implant. J Oral Implant 2003;29:174-80.  Back to cited text no. 36
    
37.Trisi P, Marcato C, Todisco M.Bone-to-implant apposition with machined and MTX microtextured implant surfaces in human sinus grafts. Int J PeriodontRestorat Dent 2003;23:427-37.  Back to cited text no. 37
    
38.Orsini G,Assenza B, Scarano A, Piattelli M, Piattelli A. Surface analysis of machined versus sandblasted and acid-etched titanium implants. Int J Oral Maxillofac Implants 2000;15:779-84.  Back to cited text no. 38
    
39.Buser D, Nydegger T, Hirt HP, Cochran DL, Nolte LP. Removal torque values of titanium implants in the maxillae of miniature pigs. Int J Oral Maxillofac Implants 1998;13:611-9.  Back to cited text no. 39
    
40.Cochran DL, Schenk RK, Lussi A, Higginbottom FL, Buser D. Bone response to unloaded and loaded titanium implant with a sandblasted and acid etched surface:A histometric study in the canine mandible. J Biomed Mater Res 1998;40:1-11.  Back to cited text no. 40
    
41.Rupp F, Scheideler L, Rehbein D, Axmann D, Geis-Gerstorfer J. Roughness induced dynamic changes of wettability of aid etched titanium implant modifications. Biomaterials 2004;25:1429-38.  Back to cited text no. 41
    
42.Degidi M, Piattelli A, Shibli JA, Perrotti V, Iezzi G. Bone formation around one-stage implants with a modified sandblasted and acid-etched surface:Human histologic results at 4 weeks.Int J PeriodontRestorat Dent 2009;29:607-13.  Back to cited text no. 42
    
43.Schätzle M, Männchen R, Balbach U, Hämmerle CH, Toutenburg H, Jung RE. Stability change of chemically modified sandblasted/acid-etched titanium palatal implants:A randomized-controlled clinical trial. Clin Oral Implants Res 2009;20:489-95.  Back to cited text no. 43
    
44.Oates TW, Valderrama P, Bischof M, Nedir R, Jones A, Simpson J, et al. Enhanced implant stability with a chemically modified SLA surface: A randomized pilot study. Int J Oral Maxillofac Implants 2007;22:755-60.  Back to cited text no. 44
    
45.Trisi P, Lazzara R, Rao W, Rebaudi A.Bone-implant contact and bone quality:Evaluation of expected and actual bone contact on machined and osseotite implant surfaces. Int J Periodontics Restorative Dent 2002;22:535-45.  Back to cited text no. 45
    
46.Lazzara RJ, Testori T, Trisi P, Porter SS, Weinstein RL. A human histologic analysis of osseotite and machined surfaces using implants with 2 opposing surfaces. Int J PeriodontRestorat Dent 1999;19:117-29.  Back to cited text no. 46
    
47.Grassi S, Piattelli A, Ferrari DS, Figueiredo LC, Feres M, Iezzi G, et al. Histologic evaluation of human bone integration on machined and sandblasted acid-etched titanium surfaces in type IV bone. J Oral Implantol 2007;33:8-12.  Back to cited text no. 47
    
48.Cochran D, Oates T, Morton D, Jones A, Buser D, Peters F. Clinical field trial examining an implant with a sand-blasted, acid-etched surface. J Periodontol 2007;78:974-82.  Back to cited text no. 48
    
49.Roccuzzo M, Wilson T. A prospective study evaluating a protocol for 6 weeks' loading of SLA implants in the posterior maxilla:One year results. Clin Oral Implants Res 2002;13:502-7.  Back to cited text no. 49
    
50.Cochran DL, Buser D, ten Bruggenkate CM, Weingart D, Taylor TM, Bernard JP, et al. The use of reduced healing times on ITI implants with a sandblasted and acid-etched (SLA) surface:Early results from clinical trials on ITI SLA implants. Clin Oral Implants Res 2002;13:144-53.  Back to cited text no. 50
    
51.Lazzara RJ, Porter SS, Testori T, Galante J, Zetterqvist L.A prospective multicenter study evaluating loading of osseotite implants two months after placement:One-year results. J Esthet Dent 1998;10:280-9.   Back to cited text no. 51
    
52.Li LH, Kong YM, Kim HW, Kim YW, Kim HE, Heo SJ, et al. Improved biological performance of Ti implants due to surface modification by micro-arc oxidation. Biomaterials 2004;25:2867-75.  Back to cited text no. 52
    
53.Shibli JA, Grassi S, de Figueiredo LC, Feres M, Marcantonio E Jr, Iezzi G, et al. Influence of implant surface topography on early osseointegration:A histological study in human jaws. J Biomed Mater Res B ApplBiomater 2007;80:377-85.  Back to cited text no. 53
    
54.Ivanoff CJ, Widmark G, Johansson C, Wennerberg A.Histologic evaluation of bone response to oxidized and turned titanium micro-implants in human jawbone. Int J Oral Maxillofac Implants 2003;18:341-8.  Back to cited text no. 54
    
55.Sul YT, Johansson CB, Jeong Y, Wennerberg A, Albrektson T. Resonance frequency and removal torque analysis of implants with turned and anodized surface oxide. Clin Oral Implants Res 2002;13:252-9.  Back to cited text no. 55
    
56.Al-Nawas B, Götz H. Three-dimensional topographic and metrologic evaluation of dental implants by confocal laser scanning microscopy. Clin implant Dent Relat Res 2003;5:176-83.  Back to cited text no. 56
    
57.Franchi M, Bacchelli B, Martini D, Pasquale VD, Orsini E, Ottani V, et al. Early detachment of titanium particles from various different surfaces of endosseous dental implants. Biomaterial 2004;25:2239-46.  Back to cited text no. 57
    
58.d'Hoedt B, Schulte W. A comparative study of results with various endosseous implant systems. Int J Oral Maxillofac Implants 1989;4:95-105.  Back to cited text no. 58
    
59.de Groot K, Wolke JG, Jansen JA. Calcium phosphate coatings for medical implants. ProcInstMechEng H 1998;212:137-47.  Back to cited text no. 59
    
60.Davies JE. Understanding peri-implant endosseous healing. J Dent Educ 2003;67:932-49.  Back to cited text no. 60
    
61.Zeng H, Chittur KK, Lacefield WR. Analysis of bovine serum albumin adsorption on calcium phosphate and titanium surfaces. Biomaterials 1999;20:377-84.  Back to cited text no. 61
    
62.Hayashi K, Mashima T, Uenoyama K. The effect of hydroxyapatite coating on bony ingrowth into grooved titanium implants. Biomaterials 1999;20:111-9.  Back to cited text no. 62
    
63.Hayashi K, Inadome T, Tsumura H, Nakashima Y, Sugioka Y. Effect of surface roughness of hydroxyapatite-coated titanium on the bone-implant interface shear strength. Biomaterials 1994;15:1187-91.  Back to cited text no. 63
    
64.Moroni A, Caja VL, Egger EL, Trinchese L, Chao EY. Histomorphometry of hydroxyapatite coated and uncoated porous titanium bone implant. Biomaterials 1994;15:926-30.  Back to cited text no. 64
    
65.Fend B, Weng J, Yangm BC, Qu SX, Zhang XD. Characterization of titanim surfaces with calcium and phosphate and osteoblast adhesion. Biomaterials 2004;25:3421-8.  Back to cited text no. 65
    
66.Strnad Z, Strnad J, Povýsil C, Urban K.Effect of plasma-sprayed hydroxyapatite coating on the osteoconductivity of commercially pure titanium implants. Int J Oral Maxillofac Implants 2000;15:483-90.  Back to cited text no. 66
    
67.Gottlander M, Johansson CB, Albrektsson T. Short- and long-term animal studies with a plasma-sprayed calcium phosphate-coated implant. Clin Oral Implants Res 1997;8:345-55.  Back to cited text no. 67
    
68.Yoshinari M, Klinge B, Dérand T. The biocompatibility (cell culture and histologic study) of hydroxyapatite-coated implants created by ion beam dynamic mixing method. Clin Oral Implants Res 1996;7:96-100.  Back to cited text no. 68
    
69.Yoshinari M, Ohtsuka Y, Dérand T. Thin hydroxyapatite coating produced by the ion beam dynamic mixing method. Biomaterials 1994;15:529-35.  Back to cited text no. 69
    
70.Yang Y, Kim KH, Ong JL. A review on calcium phosphate coatings produced using a sputtering process: An alternative to plasma spraying. Biomaterials 2005;26:327-37.  Back to cited text no. 70
    
71.Ong JL, Bessho K, Cavin R, Carnes DL. Bone response to radio frequency sputtered calcium phosphate implants and titanium implants In vivo. J Biomed Mater Res 2002;59:184-90.  Back to cited text no. 71
    
72.Wolke JG, de Groot K, Jansen JA. In vivo dissolution behavior of various RF magnetron sputtered Ca-P coatings. J Biomed Mater Res1998;39:524-30.  Back to cited text no. 72
    
73.Thian ES, Huang J, Best SM, Barber ZH, Bonfield W. Magnetron co-sputtered silicon-containing hydroxyapatite thin films: An In vitro study. Biomaterials 2005;26:2947-56.  Back to cited text no. 73
    
74.Jansen JA, Wolke JG, Swann S, Van der Waerden JP, de Groot K. Application of magnetron sputtering for producing ceramic coatings on implant materials. Clin Oral Implants Res 1993;4:28-34.  Back to cited text no. 74
    
75.Wolke JG, van Dijk K, Schaeken HG, de Groot K, Jansen JA. Study of the surface characteristics of magnetron-sputter calcium phosphate coatings. J Biomed Mater Res 1994;28:1477-84.  Back to cited text no. 75
    
76.Kim HW, Kim HE, Knowles JC. Fluor-hydroxyapatite sol-gel coating on titanium substrate for hard tissue implants. Biomaterials 2004;25:3351-8.  Back to cited text no. 76
    
77.Nguyen HQ, Deporter DA, Pilliar RM, Valiquette N, Yakubovich R.The effect of sol-gel-formed calcium phosphate coatings on bone ingrowth and osteoconductivity of porous-surfaced Ti alloy implants. Biomaterials 2004;25:865-76.  Back to cited text no. 77
    
78.Ramires PA, Wennerberg A, Johansson CB, Cosentino F, Tundo S, Milella E. Biological behavior of sol-gel coated dental implants. J Mater Sci Mater Med 2003;14:539-45.  Back to cited text no. 78
    
79.Kim HW, Kim HE, Salih V, Knowles JC. Sol-gel-modified titanium with hydroxyapatite thin films and effect on osteoblast-like cell responses. J Biomed Mater Res A 2005;74:294-305.  Back to cited text no. 79
    
80.Vasanthan A, Kim H, Drukteinis S, Lacefield W. Implant surface modification using laser guided coatings:In vitro comparison of mechanical properties. J Prosthodont 2008;17:357-64.  Back to cited text no. 80
    
81.Zabetakis PM, Cotell CM, Chrisey DB, Auyeung RC. Pulsed laser deposition of thin film hydroxyapatite:Applications for flexible catheters. ASAIO J 1994;40:M896-9.  Back to cited text no. 81
    
82.Blind O, Klein LH, Dailey B, Jordan L. Characterization of hydroxyapatite films obtained by pulsed-laser deposition on Ti and Ti-6Al-4V substrates. Dent Mater 2005;21:1017-24.  Back to cited text no. 82
    
83.Lakstein D, Kopelovitch W, Barkay Z, Bahaa M, Hendel D, Eliaz N. Enhanced osseointegration of grit-blasted, NaOH-treated and electrochemically hydroxyapatite-coated Ti-6Al-4V implants in rabbits. ActaBiomater 2009;5:2258-69.   Back to cited text no. 83
    
84.Wang J, Layrolle P, Stigter M, de Groot K. Biomimetic and electrolytic calcium phosphate coatings on titanium alloy:Physicochemical characteristics and cell attachment. Biomaterials 2004;25:583-92.  Back to cited text no. 84
    
85.Kokubo T, Kushitani H, Sakka S, Kitsugi T , Yamamuro T. Solutions able to reproduce In vivo surface-structure changes in bioactive glass-ceramic A-W. J Biomed Mater Res 1990;24:721-34.  Back to cited text no. 85
    
86.Barrère F, Layrolle P, Van Blitterswijk CA, De Groot K. Biomimetic coatings on titanium:A crystal growth study of octacalcium phosphate. J Mater Sci Mater Med 2001;12:529-34.  Back to cited text no. 86
    
87.Liu Y, Layrolle P, de Bruijn J, van Blitterswijk C, de Groot K. Biomimetic coprecipitation of calcium phosphate and bovine serum albumin on titanium alloy. J Biomed Mater Res 2001;57:327-35.  Back to cited text no. 87
    
88.Lee JH, Ryu HS, Lee DS, Hong KS, Chang BS, Lee CK. Bio-mechanical and histomorphometric study on the bone-screw interface of bioactive ceramic-coated titanium screws. Biomaterials 2005;26:3249-57.  Back to cited text no. 88
    
89.de Groot K, Geesink R, Klein CP, Serekian P. Plasma sprayed coatings of hydroxyapatite. J Biomed Mater Res 1987;21:1375-81.  Back to cited text no. 89
    
90.de Groot K. Hydroxyapatite coated implants. J Biomed Mater Res 1989;23:1367-71.  Back to cited text no. 90
    
91.Klein CP, Patka P, Wolke JG, de Blieck-Hogervorst JM, de Groot K. Long-term In vivo study of plasma-sprayed coatings on titanium alloys of tetracalcium phosphate, hydroxyapatite and alpha-tricalcium phosphate. Biomaterials 1994;15:146-50.  Back to cited text no. 91
    
92.Morris HF, Ochi S. Survival and stability (PTVs) of six implant designs from placement to 36 months. Ann Periodontol 2000;5:15-21.  Back to cited text no. 92
    
93.Jeffcoat MK, McGlumphy EA, Reddy MS, Geurs NC, Proskin HM. A comparasion of hydroxyapatite (HA)-coated threaded, HA-coated cylindric and titanium threaded endosseous dental implants. Int J Oral Maxillofac Implants 2003;18:406-10.  Back to cited text no. 93
    
94.McGlumphy EA, Peterson LJ, Larsen PE, Jeffcoat MK. Prospective study of 429 hydroxyapatite coated cylindricomniloc implants placed in 121 patients. Int J Oral Maxillofac Implants 2003;18:82-92.  Back to cited text no. 94
    
95.Porter AE, Taak P, Hobbs LW, Coathup MJ, Blunn GW, Spector M. Bone bonding to hydroxyapatite and titanium surfaces on femoral stems retrieved from human subjects at autopsy. Biomaterials 2004;25:5199-208.  Back to cited text no. 95
    
96.Denissen HW, Kalk W, Veldhuis AA, van den Hooff A. Eleven years of study of hydroxyapatite implants. J Prosthet Dent 1989;61:706.  Back to cited text no. 96
    
97.Lee EJ, Lee SH, Kim HW, Kong YM, Kim HE. Fluoridated apatite coatings on titanium obtained by electron-beam deposition. Biomaterials 2005;26:3843-51.   Back to cited text no. 97
    
98.Dávid A, Eitenmüller J, Muhr G, Pommer A, Bär HF, Ostermann PA, et al. Mechanical and histological evaluation of hydroxyapatite-coated, titanium-coated and grit-blasted surfaces under weight-bearing conditions.Arch Orthop Trauma Surg 1995;114:112-8.  Back to cited text no. 98
    
99.Inadome T, Hayashi K, Nakashima Y, Tsumura H, Sugioka Y. Comparison of bone-implant interface shear strength of hydroxyapatite-coated and alumina-coated metal implants. J Biomed Mater Res 1995;29:19-24.  Back to cited text no. 99
    
100.Rohanizadeh R, Al-Sadeq M, LeGeros RZ. Preparation of different forms of titanium oxide on titanium surface:Effects on apatite deposition. J BioMed Mater Res A 2004;71:343-52.  Back to cited text no. 100
    
101.Zhang Q, Leng Y, Xin R. A comparative study of electrochemical deposition and biomimetic deposition of calcium phosphate on porous titanium. Biomaterials 2005;26:2857-65  Back to cited text no. 101
    
102.Goené RJ, Testori T, Trisi P. Influence of a nanometer-scale surface enhancement on de novo bone formation on titanium implants:A histomorphometric study in human maxillae. Int J PeriodontRestorat Dent 2007;27:211-9.  Back to cited text no. 102
    
103.Oh S, Daraio C, Chen LH, Pisanic TR, Fiñones RR, Jin S. Significantly accelerated osteoblast cell growth on aligned TiO2 nanotubes. J BioMed Mater Res A 2006;78:97-103.  Back to cited text no. 103
    
104.Sato M, Sambito MA, Aslani A, Kalkhoran NM, Slamovich EB, Webster TJ. Increased osteoblast functions on undoped and yttrium-doped nanocrystalline hydroxyapatite coatings on titanium. Biomaterial 2006;27:2358-69.  Back to cited text no. 104
    
105.Hollander DA, von Walter M, Wirtz T, Sellei R, Schmidt-Rohlfing B, Paar O, et al. Structural, mechanical and In vitro characterization of individually structured Ti-6Al-4V produced by direct laser forming. Biomaterials 2006;27:955-63.  Back to cited text no. 105
    
106.Sato M, Slamovich EB, Webster TJ. Enhanced osteoblast adhesion on hydrothermally treated hydroxyapatite/titania/poly(lactide-co-glycolide) sol-gel titanium coatings. Biomaterials 2005;26:1349.  Back to cited text no. 106
    
107.Xie Y, Liu X, Huang A, Ding C, Chu PK. Improvement of surface bioactivity on titanium by water and hydrogen plasma immersion ion implantation. Biomaterials 2005;26:6129-35.  Back to cited text no. 107
    
108.Kim HW, Lee EJ, Jun IK, Kim HE. On the feasibility of phosphate glass and hydroxyapatite engineered coating on titanium. J BioMed Mater Res A 2005;75:656-67.  Back to cited text no. 108
    
109.Wang J, de Boer J, de Groot K. Preparation and characterization of electrodeposited calcium phosphate/chitosan coating on Ti6Al4V plates. J Dent Res 2004;83:296-301.  Back to cited text no. 109
    
110.Park JM, Koak JY, Jang JH, Han CH, Kim SK, Heo SJ.Osseointegration of anodized titanium implants coated with fibroblast growth factor-fibronectin (FGF-FN) fusion protein. Int J Oral Maxillofac Implants 2006;21:859-66.  Back to cited text no. 110
    
111.Bessho K, Carnes DL, Cavin R, Chen HY, Ong JL. BMP stimulation of bone response adjacent to titanium implants In vivo. Clin Oral Implants Res 1999;10:212-8.  Back to cited text no. 111
    
112.Tatakis DN, Koh A, Jin L, Wozney JM, Rohrer MD, Wikesjö UM. Peri-implant bone regeneration using recombinant human bone morphogenetic protein-2 in a canine model:A dose-response study. J Periodontal Res 2002;37:93-100.  Back to cited text no. 112
    
113.Wikesjö UM, Qahash M, Polimeni G, Susin C, Shanaman RH, Rohrer MD, et al. Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-2:Histologic observations. J ClinPeriodontol 2008;35:1001-10.   Back to cited text no. 113
    
114.Leknes KN, Yang J, Qahash M, Polimeni G, Susin C, Wikesjö UM. Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-2:radiographic observations. Clin Oral Implants Res 2008;19:1027-33.   Back to cited text no. 114
    
115.Meraw SJ, Reeve CM, Wollan PC. Use of alendronate in peri-implant defect regeneration. J Periodontol1999;70:151-8.  Back to cited text no. 115
    
116.Yoshinari M, Oda Y, Ueki H, Yokose S. Immobilization of bisphosphonates on surface modified titanium. Biomaterials 2001;22:709-15.  Back to cited text no. 116
    
117.Kajiwara H, Yamaza T, Yoshinari M, Goto T, Iyama S, Atsuta I, et al. The bisphosphonate pamidronate on the surface of titanium stimulates bone formation around tibial implants in rats. Biomaterials 2005;26:581-7.  Back to cited text no. 117
    
118.Dunn DS, Raghavan S, Volz RG. Gentamicin sulfate attachment and release from anodized Ti-6Al-4V orthopedic materials. J BioMed Mater Res 1993;27:895-900.  Back to cited text no. 118
    
119.Petty W, Spanier S, Shuster JJ. Prevention of infection after total joint replacement. J Bone JoIntSurgAm 1988;70:536-9.  Back to cited text no. 119
    

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Correspondence Address:
Bikash Pattanaik
Department of Prosthodontics, Rungta College of Dental Sciences and Research Centre, Bhilai, Chattisgarh
India
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DOI: 10.4103/0970-9290.102240

PMID: 23059581

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