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ORIGINAL RESEARCH Table of Contents   
Year : 2011  |  Volume : 22  |  Issue : 6  |  Page : 879
Proliferative and morphologic characterization of buccal mucosal fibroblasts in areca nut chewers: A cell culture study


1 Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Chennai, India
2 Department of Oral and Maxillofacial Pathology, Indira Gandhi Institute of Dental Sciences, Kothamangalam, India

Correspondence Address:
Deepu George Mathew
Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Chennai
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-9290.94693

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Objective: To isolate, culture and characterize fibroblasts from the buccal mucosa of areca nut chewers with and without oral submucous fibrosis (OSF). Materials and Methods: Primary fibroblast cultures were established by the collagenase disaggregation technique and the phenotypic and growth characteristics were studied. Results: Cells cultured from OSF showed a statistically significant increase in both the post-mitotic fibroblast subpopulation and the population doubling time when compared with controls. Conclusion: There was a significant increase in the pro-fibrotic, post-mitotic subpopulation of fibroblasts in areca nut chewers with OSF.


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