Indian Journal of Dental ResearchIndian Journal of Dental ResearchIndian Journal of Dental Research
HOME | ABOUT US | EDITORIAL BOARD | AHEAD OF PRINT | CURRENT ISSUE | ARCHIVES | INSTRUCTIONS | SUBSCRIBE | ADVERTISE | CONTACT
Indian Journal of Dental Research   Login   |  Users online: 44

Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size         

 


 
Table of Contents   
SHORT COMMUNICATION  
Year : 2011  |  Volume : 22  |  Issue : 6  |  Page : 850-852
Report of rare palatal expression of Nevus of Ota with amendment of Tanino's classification


Department of Oral Medicine and Radiology, JSS Dental College and Hospital, JSS University, Mysore, India

Click here for correspondence address and email

Date of Submission04-Mar-2010
Date of Decision06-Sep-2010
Date of Acceptance19-Apr-2011
Date of Web Publication5-Apr-2012
 

   Abstract 

Nevus of Ota, a benign melanocytic pigmentary disorder with rare malignant transformation potential, affects 0.014-0.034% of the Asian and Black population and has a strong predilection for females. It occurs in the area innervated by the first and second division of the trigeminal nerve. Oral manifestation is rarely noted with only 14 cases reported till date. This report documents a case of Nevus of Ota with the infrequently noted oral involvement, in an Indian lady. Since oral manifestation is not acknowledged in Tanino's classification, the authors propose a modification to the same.

Keywords: Congenital, Nevus of Ota, oral, palate, unilateral

How to cite this article:
Guledgud MV, Patil K, Srivathsa SH, Malleshi SN. Report of rare palatal expression of Nevus of Ota with amendment of Tanino's classification. Indian J Dent Res 2011;22:850-2

How to cite this URL:
Guledgud MV, Patil K, Srivathsa SH, Malleshi SN. Report of rare palatal expression of Nevus of Ota with amendment of Tanino's classification. Indian J Dent Res [serial online] 2011 [cited 2014 Oct 31];22:850-2. Available from: http://www.ijdr.in/text.asp?2011/22/6/850/94684
Oculodermal melanocytosis/nevus fuscoceruleus ophthalmomaxillaris/Nevus of Ota is a frequently benign, congenital and unilateral melanocytic pigmentary disorder, generally involving the area innervated by the first and second divisions of the trigeminal nerve. [1],[2] In 1916, Pusey described the case of a Chinese student with both sclera and facial pigmentation, but it was only in 1939 this melanocytic nevi was identified as a definitive entity by Japanese dermatologist M. T. Ota. [1],[2],[3]

Nevus of Ota affects mostly the Asians and the Blacks. On the contrary, in Japan, the incidence is about 1 to 2 per 1000 of the general population. [1],[4],[5] Extracutaneous association, especially ocular involvement of this entity, has been reported. [5] However, oral involvement is rarely noted.


   Case Report Top


A 36-year-old Indian lady presented to the Oral Diagnostic Clinic for evaluation of her oral health status. Incidentally, she also presented with asymptomatic hyperpigmented macular bluish-black extensive lesion involving the right side of the scalp, forehead, temple, zygomatic arch, periorbital area, sclera, lower palpebra, and radix of the nose with interspersed pinpoint lentigo-like spots [Figure 1], [Figure 2] and [Figure 3]. On intraoral evaluation, a similar well-defined lesion with uniform bluish-black appearance measuring approximately 1.5 × 2 cm on the right side of the posterior part of the hard palate bordering the midline was observed [Figure 4]. These pigmentations were congenital in origin, with no history of any deleterious habits or positive family history for similar lesions.
Figure 1: Exhibiting facial pigmentation

Click here to view
Figure 2: Profile view showing facial pigmentation on right side of face

Click here to view
Figure 3: Corneal pigmentation

Click here to view
Figure 4: Palatal pigmentation

Click here to view


Tympanic membrane involvement was not noted and ophthalmic investigation did not reveal any evidence of cataract or glaucoma. The clinical status did not suggest any underlying systemic disorder.

A diagnosis of Nevus of Ota was established as evidenced by the clinical findings. The need for regular follow-up has been impressed upon the patient owing to the lesions' malignant transformation potential.


   Discussion Top


Nevus of Ota, or nevus fuscoceruleus ophthalmomaxillaris, is a dermal melanocytic hamartoma that demonstrates bluish hyperpigmentation along the ophthalmic and maxillary divisions of the trigeminal nerve. [5] It can be either congenital or acquired during adolescence. [4],[5] Most patients have no positive family history. [5]

It has been hypothesized that the nevoid cells originate from Schwann cells or other neural elements, and that abnormalities of neural crest migration lead to these congenital dermal melanoses. [5] Due to female preponderance, female sex hormones have been suggested as potent stimuli. Other implicated stimuli include infection, trauma, or ultraviolet light exposure. [5]

Nevus of Ota mostly appears as an unilateral, macular, rarely papular or nodular, patchy brown, slate-blue or blue-black pigmentation, with deeper lesions appearing blue due to Tyndall effect. [3],[4],[6] Intermingling of lentigo-like spots also may be noted. About 11% lesions are bilateral. The eyelids, sclera, bulbar and palpebral conjunctiva, cornea, iris, retina, optic nerve, extraocular muscles, retrobulbar fat, the cheeks, forehead, scalp, the pharynx, the nasal mucosa, the tympanic membrane, and leptomeninges may be involved. [4],[6] Oral mucosal association, though common in Japanese, is extremely rare in non-orientals. Any area of the oral cavity can be affected but the palatal mucosa prevails. The oral lesion is depicted as irregularly shaped, macular and bluish area. [6] Review of literature yielded evidence of only 14 cases of Nevus of Ota involving the oral mucosa, of which majority of them were noted on the hard palate. [3],[7]

Based on the extent of the involvement, Tanino's classified Nevus of Ota as follows: [3],[5],[8]

Type I: IA - Mild orbital type: Upper and lower eyelids, periorbital, and temple region, IB - Mild zygomatic type: Infrapalpebral fold, nasolabial fold, and the zygomatic region, IC - Mild forehead type: Forehead alone, ID - Ala nasi alone.

Type II: Moderate type: Over the upper and lower eyelids, periocular, zygomatic, cheek, and temple regions.

Type III: The lesion involves the scalp, forehead, eyebrow, and nose.

Type IV: Bilateral type.

Oral lesions, which are rare yet significant are not represented in the above classification, which prompted the authors to propose a modification to the above classification and include oral mucosa manifestation as subclass IE. Diseases associated with Ota's nevus in rare cases are open-angle glaucoma, uveitis, cataract, and melanoma. [4],[5]

Elongated dendritic melanocytes scattered widely in the papillary to mid reticular dermis are observed histologically, which stain weakly with 3,4-dihydroxyphenylalanine, connotes that they retain the ability to generate melanin. [4],[5],[9] Intriguing observation is that the melanosomes in cells cultured from Ota's nevus are in part abnormal, almost emulating those found in dysplastic nevi and melanoma. [4]

Although diagnosis of Nevus of Ota can be made solely based on its striking clinical characteristics, other entities that need to be particularly considered are Nevus of Ito, Mongolian spots, blue nevus, and Acquired Bilateral Nevus of Ota like Macules (ABNOM), owing to their clinical resemblance. [5],[6],[7]

Nevus of Ito has features similar to that of Ota's nevus, except that it occurs along the distribution of the posterior supraclavicular and lateral cutaneous branchial nerves, involving the shoulder, neck, supraclavicular area, and upper arm. [3],[10] The Mongolian spot is congenital and involves the lumbosacral area and frequently regresses at about the age of 5 to 7 years. [4],[11] The diagnosis of above entities is essentially clinical owing to their similar histopathological features, thus eliminating the need for diagnostic biopsy. [5],[11] The blue nevus is usually papular and found on skin, with rare palatal mucosal involvement, in which the dermal melanocytes in the plaque-type variant being deeper and dense than in the Nevus of Ota. [4],[5] ABNOM is clinically distinguished by speckled or coalescent brownish-blue or slate-gray pigmentation over the face with no oral mucosa and eye involvement and histologically by diffuse upper dermal melanocytosis. [5],[6]

Laser is the therapy of choice, though dermabrasion, dermabrasion with autologous cultured epithelium grafting, and combination of sequential dry ice, and epidermal peeling has been attempted. [4],[5] Spontaneous regression has not been reported. [4],[7]


   Conclusion Top


Nevus of Ota with oral involvement is seldom noted. To give the rare oral manifestation of this entity its due recognition, the authors propose a modification to Tanino's classification. Recognition and constant vigilance serve as the cornerstones in management of this not so common entity.

 
   References Top

1.Ota M. Nevus fuscocoerulens ophthalmomaxillaris. Tokio Med J 1939;63:1243-5.  Back to cited text no. 1
    
2.Patel BC, Egan CA, Lucius RW, Gerwels JW, Mamalis N, Anderson RL. Cutaneous malignant melanoma and oculodermal melanocytosis (nevus of Ota): Report of a case and review of the literature. J Am Acad Dermatol 1998;38:862-5.  Back to cited text no. 2
    
3.Sekar S, Kuruvila M, Pai HS. Nevus of Ota: A series of 15 cases. Indian J Dermatol Venereol Leprol 2008;74:125-7.  Back to cited text no. 3
[PUBMED]  Medknow Journal  
4.Turnbull JR, Assaf CH, Zouboulis C, Tebbe B. Bilateral naevus of Ota: A rare manifestation in a Caucasian. J Eur Acad Dermatol Venereol 2004;18:353-5.  Back to cited text no. 4
    
5.Chan HH, Kono T. Nevus of Ota: Clinical aspects and management. Skinmed 2003;2:89-98.  Back to cited text no. 5
    
6.Fistarol SK, Itin PH. Plaque-type blue nevus of the oral cavity. Dermatology 2005;211:224-33.  Back to cited text no. 6
    
7.Parihar AP, Bagewadi A, Keluskar V, Shetti A. Nevus of Ota involving palate: Case report and review. JIAOMR 2007;19:441-5.  Back to cited text no. 7
    
8.Tanino H. Naevus fusco-caeruleus ophthalmomaxillaris (OTA). Jpn J Dermatol 1939;46:107-11.  Back to cited text no. 8
    
9.Kopf AW, Weidman Al. Nevus of Ota. Arch Dermatol 1962;85:195-208.  Back to cited text no. 9
    
10.Mukhopadhyay AK. Nevus of Ota associated with nevus of Ito. Indian J Dermatol Venereol Leprol 2004;70:112-3.  Back to cited text no. 10
[PUBMED]  Medknow Journal  
11.Tanyasiri K, Kono T, Groff WF, Higashimori T, Petrovska I, Sakurai H, et al. Mongolian spots with involvement of mandibular area. J Dermatol 2007;34:381-4.  Back to cited text no. 11
    

Top
Correspondence Address:
Mahima V Guledgud
Department of Oral Medicine and Radiology, JSS Dental College and Hospital, JSS University, Mysore
India
Login to access the Email id


DOI: 10.4103/0970-9290.94684

Get Permissions



    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]



 

Top
 
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Email Alert *
    Add to My List *
* Registration required (free)  
 


    Abstract
   Case Report
   Discussion
   Conclusion
    References
    Article Figures

 Article Access Statistics
    Viewed1568    
    Printed56    
    Emailed0    
    PDF Downloaded66    
    Comments [Add]    

Recommend this journal