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ORIGINAL RESEARCH Table of Contents   
Year : 2011  |  Volume : 22  |  Issue : 5  |  Page : 639-643
Lycopene in the management of oral lichen planus: A placebo-controlled study

1 Department of Oral Medicine and Radiology, People's College of Dental Sciences and Research Centre, Bhopal, India
2 UP Dental College and Research Centre, Lucknow, India
3 Department of Oral Pathology and Microbiology, People's Dental Academy, Bhopal, India
4 Department of Oral Medicine and Radiology, KLE Institute of Dental Sciences, Belguam, India
5 Mamata Dental College and Hospital, Khammam, India
6 Genesis Institute of Dental Sciences and Research, Ferozpur, India

Correspondence Address:
Nisheeth Saawarn
Department of Oral Medicine and Radiology, People's College of Dental Sciences and Research Centre, Bhopal
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Source of Support: Study medications (Capsule Lycored & Identical Placebo) provided by Jagsonpal Pharmaceutical, New Delhi, India, Conflict of Interest: None

DOI: 10.4103/0970-9290.93448

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Context: Oxidative stress has been implicated in the pathogenesis of lichen planus, and a lower level of lycopene has been reported in erosive and atrophic oral lichen planus (OLP) patients. However, its efficacy in the management of OLP has not been reported. Aim: This study was designed to assess the efficacy of systemic lycopene in the management of OLP. Settings and Design: This prospective, randomized, double-blind, placebo-controlled study was done in the Oral Medicine Department of a postgraduate teaching dental hospital in India. Materials and Methods: Thirty symptomatic OLP patients, randomly divided into two groups of 15 each, were administered lycopene 8 mg/day and an identical placebo, respectively, for 8 consecutive weeks. Burning sensation using visual analogue scale and overall treatment response using Tel Aviv-San Francisco scale were recorded at every visit. The data obtained were analyzed statistically using Wilcoxon Rank test, Mann-Whitney and Fischer's Exact test. Results: A higher (84%) reduction in burning sensation was seen in lycopene than in the placebo group (67%). All 15 (100%) patients in the lycopene group showed 50% or more benefit and 11 (73.3%) patients showed 70-100% benefit, while this number was only 10 and 4 (26.7%), respectively, in the placebo group. Conclusion: Lycopene was very effective in the management of OLP, and oxidative stress may have a role in disease pathogenesis.

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