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CASE REPORT Table of Contents   
Year : 2009  |  Volume : 20  |  Issue : 2  |  Page : 230-234
Odontoameloblastoma: Report of two cases


1 Department of Molecular Biology, IPEN, São Paulo, Brazil
2 Department of Dentistry, College of Odontology, University of São Paulo, Brazil
3 Department of Oral Pathology, College of Odontology, University of Paulista, São Paulo, Brazil
4 Department of Stomatology and Maxillofacial Surgery, Heliopolis Hospital, São Paulo, Brazil
5 Department of Stomatology, College of Odontology, University of São Paulo, Brazil

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Date of Submission16-Jan-2008
Date of Decision01-Mar-2008
Date of Acceptance16-Jun-2008
Date of Web Publication23-Jun-2009
 

   Abstract 

Odontoameloblastoma (OA) is a very rare mixed odontogenic neoplasm, characterized by the simultaneous occurrence of an ameloblastoma and a compound or complex odontoma in the same tumor mass. To date, less than 50 cases of OA and/or ameloblastic odontoma have been reported in the English dental literature. This neoplasm was called ameloblastic odontoma. The term OA was included in the 1971 WHO classification. In this study, we present two cases of OA, which we hope will contribute to the awareness and knowledge of surgeons regarding the existence of this odontogenic tumor so that patients having it may be treated and followed-up properly.

Keywords: Ameloblastoma, mixed odontogenic tumors, odontoameloblastoma, odontogenic tumors, odontoma

How to cite this article:
Mosca RC, Marques MM, Barbosa SC, Marcucci M, Oliveira JX, Lascala CA. Odontoameloblastoma: Report of two cases. Indian J Dent Res 2009;20:230-4

How to cite this URL:
Mosca RC, Marques MM, Barbosa SC, Marcucci M, Oliveira JX, Lascala CA. Odontoameloblastoma: Report of two cases. Indian J Dent Res [serial online] 2009 [cited 2014 Oct 31];20:230-4. Available from: http://www.ijdr.in/text.asp?2009/20/2/230/52890
Odontoameloblastoma (OA) is an extremely rare odontogenic tumor that contains an ameloblastomatous component together with odontoma-like elements. [1] It is similar to an ameloblastoma, both in structure and in behavior. [2] This tumor was formerly called ameloblastic odontoma. Thoma et al. [3] described the first case in 1944 and since the first edition of the WHO Histological Classification of Odontogenic Tumours, [4],[5] the OA still appears as a distinct odontogenic neoplasm. [6] To date, there are less than 50 cases that have been reported as OA and/or ameloblastic odontoma in the English dental literature. [7],[8] The epithelial proliferation portion of the tumor forms islands or cords resembling the follicular or plexiform pattern typical of an ameloblastoma. This ameloblastic component is intermingled with dental tissues of variable degrees of maturity, as seen in odontomas. [1] We present two cases of OA with different clinical characteristics, except for the fact that both occurred in young patients.


   Case Reports Top


Case 1

The patient, a 22-year-old black woman was referred to the clinic because of a swelling located in the left upper area of the vestibule of the mouth. Extraoral examination revealed a discrete swelling of both the left upper lip and the nose wing [Figure 1a]. Intraorally, a painless swelling on the left side of the maxilla extending from the central incisor to the first premolar was observed [Figure 1b] and [Figure 1c]. Even though these teeth were slightly mobile, they were still vital. The consistency of the swelling was uniformly hard and the overlying mucosa was purple. The past medical history of the patient was non-contributory. Radiographic examination included occlusal [Figure 2a] and periapical [Figure 2b] radiographs. A cyst-like intraosseous lesion was found with a well-defined margin. The lesion was located in the apical region of the left central incisor, lateral incisor, canine and first premolar. These teeth presented root resorption [Figure 2a] and [Figure 2b]. The lesion, exhibiting different levels of radiolucence, did not cross to the right side of the maxilla. At the uppermost side of the lesion, a radiopaque mass with radiodensity similar to that of the dentine was present. An adenomatoid odontogenic tumor, a calcifying epithelial odontogenic tumor and an ameloblastic fibroodontoma were considered as differential diagnoses. An incisional biopsy was planned under local anesthesia; however, during the surgical procedure, the lesion was wholly detached, resulting in an excisional biopsy [Figure 1c]. The tumor was surgically enucleated with a 2mm safety margin and the material was fixed in a 10% formalin solution and submitted to histopathological analysis. [Figure 3a],[Figure 3b],[Figure 3c] shows the histopathological findings for the tumor. [Figure 3a] reveals areas of plexiform ameloblastoma with some cystic spaces in the stroma. Epithelial proliferation in the form of anastomosing cords could be seen. Cubical to columnar cell-surrounded areas resembling the stellate reticulum of the enamel organ were seen. These areas were surrounded by a mesenchymal component [Figure 3b]. Calcified structures were observed in the mesenchymal component [Figure 3c]. These structures resembled immature dentine (eosinophilic structure) and cementum (basophilic structure) of variable degrees of maturity. Based on the radiographic and histopathological findings, a final diagnosis of OA was made. There was no recurrence of the tumor after a 6-year follow-up.

Case 2

The patient, a 16-year-old Caucasian man, was referred to the clinic because of a swelling located in the right mandibular molar region. Extraoral examination revealed a swelling of the posterior mandible, which was hard in consistency. The lesion was painless. It had been detected and was growing slowly for the past two and a half years. The medical histories of the patient and his family were non-contributory. Intraoral examination revealed a poorly circumscribed hard swelling in the molar area. The covering mucosa was normal in color and texture. Radiographic examination included posteroanterior [Figure 2c] and lateral [Figure 2d] radiographs of the mandible. In both radiographs, a large and irregular radiopaque mass was observed circumscribed by a radiolucent rim. The radiopaque mass had globules with different degrees of radioopacity. The lesion produced an expansion of the vestibular cortical bone [Figure 2c]. Based on the clinical and radiographic examination, a diagnostic hypothesis of odontoma was considered and an excisional biopsy was indicated. The lesion was removed under general anesthesia through an extraoral access. The material was fixed in a 10% formalin solution and submitted to histopathological analysis. [Figure 3d],[Figure 3e],[Figure 3f] shows the histopathological findings for the tumor. [Figure 3d] reveals sheets of odontogenic epithelium resembling that of a solid ameloblastoma, surrounded by a mesenchymal component. Under higher magnification [Figure 3e], a proliferating odontogenic epithelium could be seen as sheets delimited by columnar epithelial cells in close contact with the mesenchymal surrounding tissue. Calcified structures/material was associated with the mesenchymal component [Figure 3f]. These structures had the morphological features of immature dentine (eosinophilic structure) and cementum (basophilic structure). Based on the radiographic and histopathological findings, a final diagnosis of OA was made. There was no clinical or radiographic evidence of recurrence of the tumor after a 6-month follow-up.


   Discussion Top


Because of the rarity of OAs, little reliable information is available. According to Mosqueda-Taylor et al., [7] only 14 cases reported in the literature met the WHO histological and clinical criteria to be classified as OAs. In their review of the literature, these authors discussed all the misdiagnosed lesions that were confused with OAs, especially when ghost cells were present in the tumors. [9],[10] The incidence of OAs is very low. In a review of 164 odontogenic tumors, Stypulkowska [11] found a single case of OA (0.6%). In another review of 108 odontogenic tumors previously diagnosed as ameloblastomas, Raubenheimer et al., [12] also found a single case of OA (0.9%).

Radiographically, the tumor presents a radiolucent, destructive process that contains calcified structures resembling mature dental tissue. These radiographic features were seen in our cases.

OAs have clinical and microscopic characteristics that allow them to be differentiated from typical ameloblastomas and odontomas. They occur in young patients and have a predilection for males. [4],[5] Pain, delayed eruption of teeth and expansion of the affected bone may be observed. As regards location, according to Mosqueda-Taylor et al., [7] the tumor can affect both the maxilla and the mandible equally, whereas Martνn-Granizo López et al. [8] found that there is a slight tendency toward greater involvement of the mandible.

Because OAs are rare, only case reports and literature reviews citing these cases are available, except for the study by Yamamoto et al., [13] who studied the behavior of the tumor by analyzing proteins of the extracellular matrix of the basement membrane. No studies were found establishing the pathogenesis of this neoplasm. Nevertheless, some theoretical explanations were presented. According to Thompson et al., [14] the proliferating epithelium could induce the mesenchymal tissue to form hamartomatous mineralized dental tissue. Mosqueda-Taylor et al. [7] presented another possibility: The coexistence of an ameloblastoma and an odontoma. They would develop separately and then collide. The same authors, however, discarded this explanation based on the clinical aspects of these pathological entities and, especially, on the microscopic features of the OA, which clearly show an intimate relationship between the ameloblastoma and the mineralized tissues.

The histopathological features of the OA are complex. There is a proliferating odontogenic epithelium portion similar to that of an ameloblastoma, generally presenting a plexiform or follicular pattern. This epithelial portion appears intermingled with dental tissues of variable degrees of maturity in the form of developing rudimentary teeth, resembling a compound odontoma or conglomerate masses of enamel, dentin and cementum, as seen in a complex odontoma. [1] The cases presented here exhibited all the histopathological features of OAs. In both cases, the dental tissue was represented by masses of dentin and cementum. Enamel matrix, however, was not observed.

From a clinical and radiographic point of view, differential diagnoses include several odontogenic and non-odontogenic lesions exhibiting well-defined uni- or multilocular radiolucencies with varying amounts of radiopaque material within them. These include developing compound or complex odontomas, ameloblastic fibroodontomas, calcifying epithelial odontogenic tumors, calcifying odontogenic cystic tumors, adenomatoid odontogenic tumors and cementoossifying fibromas. Based on the clinical and radiographic findings of the first case presented here, the differential diagnosis hypotheses included an adenomatoid odontogenic tumor, a calcifying epithelial odontogenic tumor and an ameloblastic fibroodontoma. However, the resorption of adjacent tooth roots observed in this case is not usually observed in cases of an adenomatoid odontogenic tumor. Owing to a possible diagnosis of a calcifying epithelial odontogenic tumor, which behaves as an ameloblastoma, the tumor was surgically enucleated with a 2mm safety margin.

Although located in the posterior mandible, the second case presented in this study resembled that of an odontoma and, for this reason, it was only enucleated. No recurrences of the tumor were observed after a follow-up period of 6 years in the first case and 6 months in the second case.

In the review by Mosqueda-Taylor et al., [7] 3 of 14 cases recurred (21.4%). These authors emphasized that OA should be closely followed-up for at least 5 years. The patient of our second case should therefore be closely followed-up for a yet longer period of time.

The potential for OA to recur is well known. In fact, Yamamoto et al. [13] demonstrated a high proliferation potential of the OA based on the expression of tenascin in the basement membrane of the odontogenic epithelium of this tumor and on the results obtained with proliferating cell nuclear antigen (PCNA) staining. These results indicate that this tumor may have the same biologic potential as that of an ameloblastoma and should therefore be treated and followed-up in a similar fashion. [1],[7]

Because of the rarity of OAs and its similarity to other odontogenic lesions, a pre-operative diagnosis is difficult to achieve based only on the clinical and radiographic features of the lesion. [7] Nonetheless, surgeons should be aware of the existence of these odontogenic tumors in order to properly treat and follow-up patients who might present them.

 
   References Top

1.Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and Maxillofacial Pathology. Philadelphia: W.B Saunders Co; 2002.p. 605.  Back to cited text no. 1    
2.Kramer IRH, Pindborg JJ, Shear M. Histological typing of odontogenic tumours. Berlin: Springer-Verlag; 1992. p. 11.  Back to cited text no. 2    
3.Thoma KH, Johnson GJ, Ascario N. Case 43: Adamanto-odontoma.Am J Orthod Oral Surg 1944;30:244.  Back to cited text no. 3    
4.Pindborg JJ, Kramer IRH, Torloni H. Histological typing of odontogenic tumours, jaw cysts and allied lesions. Geneva: World Health Organization; 1971. p. 29.  Back to cited text no. 4    
5.Mosqueda-Taylor A. Odontoameloblastoma. In: Barnes L, Eveson J, Reichart P, Sidransky D, editors. WHO Classification of Tumours. Pathology and Genetics of Tumours of the Head and Neck. Lyon: IARC Press; 2005. p. 312.  Back to cited text no. 5    
6.Barnes L, Eveson JW, Reichart PA, Sidransky D, editors. World Health Organization Classification of Tumours. Pathology and Genetics of Head and Neck Tumours. Lyon: IARC Press; 2005. p. 284  Back to cited text no. 6    
7.Mosqueda-Taylor A, Carlos-Bregni R, Ramirez-Amador V, Palma-Guzman JM, Esquivel-Bonilla D, Hernandez-Rojas LA. Odontoameloblastoma: Clinico-pathologic study of three cases and critical review of the literature. Oral Oncol 2002;38:800-5.  Back to cited text no. 7    
8.Martin-Granizo-Lopez R, Lopez-Garcia-Asenjo J, de-Pedro-Marina M, Dominguez-Cuadrado L. Odontoameloblastoma: A case report and a review of the literature. Med Oral 2004;9:340-4.  Back to cited text no. 8    
9.Goh BT, Teh LY. Odontoameloblastoma: Report of a case. Ann Acad Med Singapore 1999;28:749-52.  Back to cited text no. 9  [PUBMED]  
10.Praetorius F, Hjorting-Hansen E, Gorlin RJ, Vickers RA. Calcifying odontogenic cyst. Range, variations and neoplastic potential. Acta Odontol Scand 1981;39:227-40.  Back to cited text no. 10    
11.Stypulkowska J. Odontogenic tumours and neoplastic-like changes of the jaw bone: Clinical study and evaluation of treatment results. Folia Med Cracov 1998;39:35-141.  Back to cited text no. 11    
12.Raubenheimer EJ, van Heerden WF, Noffke CE. Infrequent clinicopathological findings in 108 ameloblastomas. J Oral Pathol Med 1995;24:227-32.  Back to cited text no. 12  [PUBMED]  
13.Yamamoto K, Yoneda K, Yamamoto T, Ueta E, Osaki T. An immunohistochemical study of odontogenic mixed tumours. Eur J Cancer B Oral Oncol 1995;31B:122-8.  Back to cited text no. 13  [PUBMED]  
14.Thompson IO, Phillips VM, Ferreira R, Housego TG. Odontoameloblastoma: A case report. Br J Oral Maxillofac Surg 1990;28:347-9.  Back to cited text no. 14  [PUBMED]  

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Correspondence Address:
Marcia M Marques
Department of Dentistry, College of Odontology, University of São Paulo
Brazil
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DOI: 10.4103/0970-9290.52890

PMID: 19553728

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    Figures

  [Figure 1a], [Figure 1b], [Figure 1c], [Figure 2a], [Figure 2b], [Figure 2c], [Figure 2d], [Figure 3a], [Figure 3b], [Figure 3c], [Figure 3d], [Figure 3e], [Figure 3f]

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